从未分离肝素切换到低分子量肝素后肝素诱导的血小板减少:一个病例报告和文献综述。

IF 1.1 4区医学 Q3 UROLOGY & NEPHROLOGY

Clinical nephrology Pub Date : 2023-07-01 DOI:10.5414/CN110947

Fan Zhang, Yiya Yang, Lizhen Li, Li Zhang, Ying Wu, Yumei Liang, Xun Luo

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引用次数: 0

摘要

肝素诱导的血小板减少症(HIT)是一种严重的、可能危及生命的药物不良反应。这是一个抗体介导的过程，涉及血小板活化。肝素和低分子量肝素(LMWH)常规用于尿毒症患者接受血液透析。在这里，我们报告一例HIT发生在血液透析患者，她从肝素切换到低分子肝素nadroparin抗凝血液透析期间。本文对HIT的临床特点、发病率、发病机制及治疗进行了讨论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Heparin-induced thrombocytopenia after switching from unfractionated heparin to low-molecular-weight heparin: A case report and literature review.

Heparin-induced thrombocytopenia (HIT) is a severe, potentially life-threatening adverse drug reaction. It is an antibody-mediated process involving platelet activation. Heparin and low-molecular-weight heparin (LMWH) are routinely used in uremic patients undergoing hemodialysis. Here, we report a case of HIT that occurred in a hemodialysis patient after she switched from heparin to the LMWH nadroparin for anticoagulation during hemodialysis. The clinical features, incidence, mechanism, and treatment of HIT are discussed.

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来源期刊

Clinical nephrology 医学-泌尿学与肾脏学

CiteScore

2.10

自引率

9.10%

发文量

138

审稿时长

4-8 weeks

期刊介绍： Clinical Nephrology appears monthly and publishes manuscripts containing original material with emphasis on the following topics: prophylaxis, pathophysiology, immunology, diagnosis, therapy, experimental approaches and dialysis and transplantation.