基于双重过敏原暴露假说的食物过敏预防皮肤和口腔干预。

IF 3.2 Q1 PEDIATRICS
Clinical and Experimental Pediatrics Pub Date : 2024-10-01 Epub Date: 2023-06-14 DOI:10.3345/cep.2023.00045
Kiwako Yamamoto-Hanada, Yukihiro Ohya
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引用次数: 0

摘要

早期发病的特应性皮炎会增加个体发生食物过敏的风险,这表明经皮致敏可能是通过发炎的皮肤发生的。关于食物过敏的成因,双重过敏原接触假说认为,口服过敏原会导致免疫耐受,而通过发炎皮肤接触过敏原则会引起食物过敏。该假说认为,诱导口腔免疫耐受并防止通过皮肤引起食物过敏非常重要。本综述重点介绍基于双重过敏原暴露假说的突破性证据,该假说涉及皮肤和口腔干预以预防食物过敏。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Skin and oral intervention for food allergy prevention based on dual allergen exposure hypothesis.

Early-onset atopic dermatitis increases an individual's risk of food allergies, suggesting that transcutaneous sensitization may occur through inflamed skin. Regarding food allergy causation, the dual allergen exposure hypothesis proposes that oral allergen exposure leads to immune tolerance, whereas allergen exposure via inflamed skin causes food allergies. This hypothesis suggests that it is important to induce oral immune tolerance and prevent allergic food sensitization through the skin. This review focuses on the breakthrough evidence based on the dual allergen exposure hypothesis that involves both skin and oral interventions for food allergy prevention.

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来源期刊
CiteScore
8.00
自引率
2.40%
发文量
88
审稿时长
60 weeks
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