同种异体造血干细胞移植的药物基因组学:对支持疗法和调理方案的影响

IF 2.2 4区医学 Q3 HEMATOLOGY

Best Practice & Research Clinical Haematology Pub Date : 2023-06-01 DOI:10.1016/j.beha.2023.101470

Sarah A. Morris, D. Grace Nguyen, Jai N. Patel

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引用次数: 0

摘要

多年来，异基因造血干细胞移植死亡率有所下降，但治疗相关毒性和移植后并发症的预防和管理仍然具有挑战性。由于药物代谢和反应的个体间变异性，药物基因组测试的应用可能会减轻药物的不良后果。这篇综述总结了与造血干细胞移植相关的临床药物基因组应用，包括抗真菌药物、免疫抑制剂和支持性护理管理，以及新出现的调节方案的药物基因组证据。

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Pharmacogenomics in allogeneic hematopoietic stem cell transplantation: Implications on supportive therapies and conditioning regimens

Allogeneic hematopoietic stem cell transplantation mortality has declined over the years, though prevention and management of treatment-related toxicities and post-transplant complications remains challenging. Applications of pharmacogenomic testing can potentially mitigate adverse drug outcomes due to interindividual variability in drug metabolism and response. This review summarizes clinical pharmacogenomic applications relevant to hematopoietic stem cell transplantation, including antifungals, immunosuppressants, and supportive care management, as well as emerging pharmacogenomic evidence with conditioning regimens.

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来源期刊

Best Practice & Research Clinical Haematology 医学-血液学

CiteScore

4.20

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Best Practice & Research Clinical Haematology publishes review articles integrating the results from the latest original research articles into practical, evidence-based review articles. These articles seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known, covering the spectrum of clinical and laboratory haematological practice and research. Although most reviews are invited, the Editor welcomes suggestions from potential authors.