一种实用且环保的合成α-氘化羧酸的方法

IF 0.9 4区医学 Q4 BIOCHEMICAL RESEARCH METHODS

Journal of labelled compounds & radiopharmaceuticals Pub Date : 2023-02-23 DOI:10.1002/jlcr.4021

Johan Wennerberg, Klaus Dreisch

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引用次数: 0

摘要

以丙二酸为原料，在D2O的作用下经氢氘交换和脱羧反应合成了α-氘化羧酸。该方法一般，温和，高效，不需要有机溶剂或其他添加剂。产率在83% - 94%之间，无需提纯。起始材料很容易获得，α-氘化羧酸可以很容易地转化为其他标记化合物，如醇、醛、酯和酰胺。用核磁共振确认纯度和同位素纯度进行表征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A practical and environmentally friendly protocol for synthesis of α-deuterated carboxylic acids

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A practical and environmentally friendly protocol for synthesis of α-deuterated carboxylic acids

α-deuterated carboxylic acids have been synthesized from the corresponding malonic acids via hydrogen/deuterium exchange and decarboxylation in presence of D₂O. The method is general, mild and efficient and does not require organic solvents or other additives. Yields range between 83% and 94% and purification was not necessary. Starting materials were easy accessible and the α-deuterated carboxylic acids may easily be transformed to other labeled compounds such as alcohols, aldehydes, esters, and amides. Characterization with NMR confirmed purity and isotopic purity.

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来源期刊

Journal of labelled compounds & radiopharmaceuticals 医学-分析化学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Labelled Compounds and Radiopharmaceuticals publishes all aspects of research dealing with labeled compound preparation and applications of these compounds. This includes tracer methods used in medical, pharmacological, biological, biochemical and chemical research in vitro and in vivo. The Journal of Labelled Compounds and Radiopharmaceuticals devotes particular attention to biomedical research, diagnostic and therapeutic applications of radiopharmaceuticals, covering all stages of development from basic metabolic research and technological development to preclinical and clinical studies based on physically and chemically well characterized molecular structures, coordination compounds and nano-particles.