皮肤恶性黑色素瘤的肿瘤和瘤周炎症反应评估

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Radu Florin Fruntelată, Assil Bakri, George Alin Stoica, Laurenţiu Mogoantă, Nina Ionovici, George Popescu, Denisa Floriana Vasilica Pîrşcoveanu, Andrada Raicea, Marius Eugen Ciurea
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引用次数: 0

摘要

皮肤癌是最常见的癌症之一,近几十年来全球发病率不断上升。紫外线(UV)辐射是增加皮肤癌发病率的主要风险因素。在皮肤癌的两种主要形式(黑色素瘤和非黑色素瘤)中,皮肤黑色素瘤(CM)的侵袭性最强,约 80% 的死亡病例都是死于这种肿瘤。恶性黑色素瘤是由于皮肤中的黑色素细胞长期暴露于太阳光或人造紫外线而发生恶性转化。皮肤中黑色素细胞的恶性转化伴随着局部炎症反应的出现,在癌变的初期阶段,炎症反应会阻碍肿瘤的发展。长期暴露于紫外线或其他致病因素会诱发慢性炎症,通过产生炎症分子(细胞因子、趋化因子、前列腺素),形成肿瘤微环境,有利于癌变、肿瘤侵袭、转移和肿瘤 "突变细胞 "的存在,从而避免免疫系统的保护作用。我们利用免疫组化技术评估了中医肿瘤的瘤内和瘤周炎性浸润细胞。与瘤内相比,瘤周基质中的慢性炎症浸润更为强烈,由淋巴细胞、浆细胞、巨噬细胞和肥大细胞(MCs)组成,呈异质性,炎症浸润中数量最多的细胞是T淋巴细胞、浆细胞和巨噬细胞;B淋巴细胞和MCs数量较少,尤其是在瘤内。炎性细胞与肿瘤细胞、血管、结缔基质直接接触,表明炎性微环境在癌变、肿瘤侵袭、局部血管生成和肿瘤转移中起着重要作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Assessment of tumoral and peritumoral inflammatory reaction in cutaneous malignant melanomas.

Assessment of tumoral and peritumoral inflammatory reaction in cutaneous malignant melanomas.

Assessment of tumoral and peritumoral inflammatory reaction in cutaneous malignant melanomas.

Assessment of tumoral and peritumoral inflammatory reaction in cutaneous malignant melanomas.

Skin cancer is one of the most common types of cancer, with an increasing worldwide incidence in recent decades. The main risk factor for increasing the skin cancer incidence is ultraviolet (UV) radiation. Of the two major forms of skin cancer (melanomas and non-melanotic cancers), the cutaneous melanoma (CM) is the most aggressive form, causing about 80% of the deaths resulted from this type of tumor. Malignant melanoma develops through malignant transformation of melanocytes in the skin because of prolonged exposure to solar or artificial UV. The malignant transformation of the melanocytes in the skin is accompanied by the presence of a local inflammatory reaction that, in the initial stages of carcinogenesis, would oppose to tumor development. Chronic exposure to UV or other etiopathogenic factors induces chronic inflammation, which, by producing inflammatory molecules (cytokines, chemokines, prostaglandins), constitutes a tumoral microenvironment that favors carcinogenesis, tumor invasion, metastasis, and the presence of neoplastic "mutant cells" that avoid the protective action of the immune system. Using immunohistochemistry techniques, we assessed the intra- and peritumoral inflammatory infiltrate cells in CM. The chronic inflammatory infiltrate presented more intense in the peritumoral stroma compared to the intratumoral one, heterogenous, more intensely composed of lymphocytes, plasma cells, macrophages, and mast cells (MCs), the most numerous cells in the inflammatory infiltrate being T-lymphocytes, plasma cells and macrophages; B-lymphocytes and MCs were in a small number, especially intratumorally. Inflammatory cells had a direct contact with tumor cells, blood vessels, connective matrix, suggesting that the inflammatory microenvironment plays an important role in carcinogenesis, tumor invasion, local angiogenesis, and tumor metastasis.

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来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
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