腹膜透析患者血清尿素与肌酐比值的临床意义。

IF 1.5 4区医学 Q3 HEMATOLOGY

Therapeutic Apheresis and Dialysis Pub Date : 2023-12-01 Epub Date: 2023-06-22 DOI:10.1111/1744-9987.14030

Shun Tonomura, Kiyotaka Uchiyama, Takashin Nakayama, Ryunosuke Mitsuno, Daiki Kojima, Eriko Yoshida Hama, Tomoki Nagasaka, Erina Sugita Nishimura, Ei Kusahana, Rina Takahashi, Norifumi Yoshimoto, Shintaro Yamaguchi, Kohkichi Morimoto, Tadashi Yoshida, Kaori Hayashi, Takeshi Kanda, Naoki Washida, Hiroshi Itoh

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引用次数: 0

摘要

引言：我们旨在确定腹膜透析（PD）患者的血清尿素与肌酐比值与残余肾功能（RKF）之间的相关性，以及其对PD相关结果的预测价值。方法：本研究包括一项横断面研究，以评估50名帕金森病患者的血清尿素与肌酐比值和RKF之间的相关性，以及一项回顾性队列研究，以评价122名帕金森病发作患者的血清脲与肌酐比值与帕金森病相关结果之间的相关性和肌酐清除值（r = 0.60，p 结论：血清尿素/肌酐比值可作为帕金森病患者RKF的指标和预后因素。

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Clinical significance of serum urea-to-creatinine ratio in patients undergoing peritoneal dialysis.

Introduction: We aimed to determine the correlation between the serum urea-to-creatinine ratio and residual kidney function (RKF) in patients undergoing peritoneal dialysis (PD), as well as its predictive value for PD-related outcomes.

Methods: This study included a cross-sectional study to assess the correlation between serum urea-to-creatinine ratio and RKF in 50 patients on PD and a retrospective cohort study to assess the association between serum urea-to-creatinine ratio and PD-related outcomes in 122 patients who initiated PD.

Results: Serum urea-to-creatinine ratios had significant positive correlations with renal Kt/V and creatinine clearance values (r = 0.60, p < 0.001 and r = 0.61, p < 0.001, respectively). Additionally, serum urea-to-creatinine ratio was significantly associated with a lower risk of transfer to hemodialysis or PD/hemodialysis hybrid therapy (hazard ratio: 0.84, 95% confidence interval: 0.75-0.95).

Conclusion: The serum urea-to-creatinine ratio can be an indicator of RKF and a prognostic factor in patients undergoing PD.

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来源期刊

Therapeutic Apheresis and Dialysis 医学-泌尿学与肾脏学

CiteScore

3.00

自引率

10.50%

发文量

166

审稿时长

6-12 weeks

期刊介绍： Therapeutic Apheresis and Dialysis is the official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis and the Japanese Society for Dialysis Therapy. The Journal publishes original articles, editorial comments, review articles, case reports, meeting abstracts and Communications information on apheresis and dialysis technologies and treatments.