{"title":"原发性甲状腺淋巴瘤——附4例报告并文献复习。","authors":"Haoying Sun, Jinzhu Ma, Yibo Chen, Ming Liu","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the pathogenesis, clinical characteristics, diagnosis, treatment, and prognosis of primary thyroid lymphoma (PTL) for a better understanding of the disease and a more accurate PTL diagnosis, thereby preventing misdiagnosis and mistreatment.</p><p><strong>Methods: </strong>The clinical manifestations, biochemical examination, ultrasound examination, imaging examination, pathologic examination, diagnosis, and treatment of four PLT patients admitted to the Department of Thyroid and Breast Surgery of the Affiliated Hospital of Inner Mongolia Medical University from January 2010 to December 2020 were retrospectively analyzed.</p><p><strong>Results: </strong>Diffuse large B-cell lymphoma (DLBCL) expressing cluster of differentiation 20 (CD20) were detected in all four PTL patients. Hashimoto's thyroiditis (HT) with increased anti-thyroglobulin antibodies (TGAb) occurred in two PTL patients, while antithyroid peroxidase autoantibody (TPOAb) was increased in three cases. All four patients underwent surgical and chemoradiotherapy treatments. Patients were without tumors during the follow-up ranging from 8 to 55 months.</p><p><strong>Conclusion: </strong>PTL is a primary extranodal lymphoma of the thyroid and is mainly derived from B-cell non-Hodgkin's lymphoma. The pathogenesis of PTL remains unclear, but it is closely related to HT. Clinical diagnosis in this study was determined by either needle biopsy or surgical resection.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":"16 5","pages":"99-107"},"PeriodicalIF":1.1000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244227/pdf/ijcep0016-0099.pdf","citationCount":"0","resultStr":"{\"title\":\"Primary thyroid lymphoma -- report of four cases and literature review.\",\"authors\":\"Haoying Sun, Jinzhu Ma, Yibo Chen, Ming Liu\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aims to investigate the pathogenesis, clinical characteristics, diagnosis, treatment, and prognosis of primary thyroid lymphoma (PTL) for a better understanding of the disease and a more accurate PTL diagnosis, thereby preventing misdiagnosis and mistreatment.</p><p><strong>Methods: </strong>The clinical manifestations, biochemical examination, ultrasound examination, imaging examination, pathologic examination, diagnosis, and treatment of four PLT patients admitted to the Department of Thyroid and Breast Surgery of the Affiliated Hospital of Inner Mongolia Medical University from January 2010 to December 2020 were retrospectively analyzed.</p><p><strong>Results: </strong>Diffuse large B-cell lymphoma (DLBCL) expressing cluster of differentiation 20 (CD20) were detected in all four PTL patients. Hashimoto's thyroiditis (HT) with increased anti-thyroglobulin antibodies (TGAb) occurred in two PTL patients, while antithyroid peroxidase autoantibody (TPOAb) was increased in three cases. All four patients underwent surgical and chemoradiotherapy treatments. Patients were without tumors during the follow-up ranging from 8 to 55 months.</p><p><strong>Conclusion: </strong>PTL is a primary extranodal lymphoma of the thyroid and is mainly derived from B-cell non-Hodgkin's lymphoma. The pathogenesis of PTL remains unclear, but it is closely related to HT. Clinical diagnosis in this study was determined by either needle biopsy or surgical resection.</p>\",\"PeriodicalId\":13943,\"journal\":{\"name\":\"International journal of clinical and experimental pathology\",\"volume\":\"16 5\",\"pages\":\"99-107\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10244227/pdf/ijcep0016-0099.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International journal of clinical and experimental pathology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International journal of clinical and experimental pathology","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}
Primary thyroid lymphoma -- report of four cases and literature review.
Objective: This study aims to investigate the pathogenesis, clinical characteristics, diagnosis, treatment, and prognosis of primary thyroid lymphoma (PTL) for a better understanding of the disease and a more accurate PTL diagnosis, thereby preventing misdiagnosis and mistreatment.
Methods: The clinical manifestations, biochemical examination, ultrasound examination, imaging examination, pathologic examination, diagnosis, and treatment of four PLT patients admitted to the Department of Thyroid and Breast Surgery of the Affiliated Hospital of Inner Mongolia Medical University from January 2010 to December 2020 were retrospectively analyzed.
Results: Diffuse large B-cell lymphoma (DLBCL) expressing cluster of differentiation 20 (CD20) were detected in all four PTL patients. Hashimoto's thyroiditis (HT) with increased anti-thyroglobulin antibodies (TGAb) occurred in two PTL patients, while antithyroid peroxidase autoantibody (TPOAb) was increased in three cases. All four patients underwent surgical and chemoradiotherapy treatments. Patients were without tumors during the follow-up ranging from 8 to 55 months.
Conclusion: PTL is a primary extranodal lymphoma of the thyroid and is mainly derived from B-cell non-Hodgkin's lymphoma. The pathogenesis of PTL remains unclear, but it is closely related to HT. Clinical diagnosis in this study was determined by either needle biopsy or surgical resection.
期刊介绍:
The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.