肺癌组织中PD-L1的表达及其与患者病理分级、分期和生存的关系

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Vishesh Dhawan, Smita Chandra, Mansi Kala, Sushant Khanduri
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引用次数: 1

摘要

目的PD-L1是一种40 kDa的1型跨膜蛋白,可抑制免疫系统的适应性臂。PD-1与配体PD-L1的相互作用抑制细胞因子的产生,并在肺癌的进展中发挥作用。本研究旨在观察PD-L1在肺癌患者中的表达及其与组织病理分级、分期及患者生存期的关系。材料与方法本前瞻性研究纳入1年内所有经组织病理学或细胞病理学检查诊断为肺癌的新病例。统计分析所有病例的PD-L1免疫表达,并根据肿瘤比例评分(Tumor Proportion Score)进行分级,并与患者的组织病理分级、分期、生存期相关。结果本组肺癌56例,PD-L1阳性64.2%,其中非小细胞肺癌占44.6%,小细胞肺癌占19.6%。其中淋巴血管浸润32.1%,坏死53.5%,HPF大于5/10的有丝分裂值37.5%为PD-L1阳性表达。配对细胞阻滞和组织病理学显示70%的PD-L1表达一致性。16.1%的cT3N1M0病例和25%的IIIA期病例显示PD-L1阳性。总的来说,60.7%的PD-L1表达阳性的患者在诊断后的12个月内无法存活。结论PD-L1免疫表达在肺癌中升高,并与淋巴血管侵袭、坏死、有丝分裂活性升高等组织形态学特征不良有关。PD-L1与12个月生存率降低和IIIA期癌相关。因此,它可能有助于从PD-L1靶向治疗中获益的患者分层。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Expression of PD-L1 in Lung Carcinoma and Its Correlation with Histopathological Grade, Stage, and Survival of Patients.

Expression of PD-L1 in Lung Carcinoma and Its Correlation with Histopathological Grade, Stage, and Survival of Patients.

Expression of PD-L1 in Lung Carcinoma and Its Correlation with Histopathological Grade, Stage, and Survival of Patients.

Expression of PD-L1 in Lung Carcinoma and Its Correlation with Histopathological Grade, Stage, and Survival of Patients.

Objective  PD-L1, a 40 kDa type 1 transmembrane protein, suppresses the adaptive arm of the immune system. The interaction of PD-1 with the ligand PD-L1 inhibits cytokine production and plays a role in the progression of lung cancer. The present study was performed to observe the expression of PD-L1 in lung carcinoma patients and its correlation with histopathological grade, stage, and survival of patients. Materials and Methods  This prospective study included all new cases of lung carcinoma diagnosed on histopathological or cytopathological examination over a period of 1 year. PD-L1 immunoexpression was statistically analyzed and graded according to the Tumor Proportion Score in all cases and correlated with histopathological grade, stage, and survival of patients. Results  This study included 56 cases of lung carcinoma with 64.2% cases showing PD-L1 positivity, out of which 44.6% were non-small cell and 19.6% were small cell lung carcinoma. In all, 32.1% cases with lymphovascular invasion, 53.5% with necrosis, and 37.5% cases with greater than 5/10 HPF mitotic figures showed positive PD-L1 expression. Paired cell blocks and histopathology showed 70% concordance for PD-L1 expression. 16.1% cT3N1M0 cases and 25% stage IIIA cases showed PD-L1 positivity. In all, 60.7% patients with positive PD-L1 expression did not survive for 12 months following diagnosis. Conclusion  PD-L1 immunoexpression was increased in lung carcinoma cases and was associated with poor histomorphological features including lymphovascular invasion, necrosis, and increased mitotic activity. PD-L1 correlated with cases having decreased 12-month survival and stage IIIA carcinoma. Thus, it may be useful in the stratification of patients who benefit from the PD-L1 targeted therapy.

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来源期刊
Journal of Laboratory Physicians
Journal of Laboratory Physicians MEDICINE, GENERAL & INTERNAL-
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审稿时长
31 weeks
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