癌症幸存者的房颤——系统回顾和荟萃分析。

IF 3.2 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
Yueyang Bao, John Lee, Udit Thakur, Satish Ramkumar, Thomas H Marwick
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引用次数: 0

摘要

背景:心房颤动(AF)是癌症治疗过程中常见的心脏并发症。目前尚不清楚癌症幸存者与人群相比是否增加了房颤风险。目前建议≥65岁的患者进行房颤筛查,但在肿瘤人群中没有具体的建议。我们试图比较癌症幸存者与一般人群的房颤检出率。方法:我们检索Pubmed, Embase和Web of Science数据库,使用与AF和癌症相关的搜索词映射到主题标题。我们纳入了英语语言研究,仅限于18岁以上、癌症治疗完成后12个月以上的成年人。使用随机效应模型,我们计算了整体AF检出率。进行meta回归分析以评估研究异质性的潜在原因。结果:共纳入16项研究。所有研究中合并心房颤动检出率为4.7% (95% ci . 4.0-5.4%),相当于合并年化心房颤动检出率为0.7% (95% ci . 0.1-0.98%)。研究之间存在显著的异质性(I2 = 99.8%, p 2 = 99.9%, p)结论:由于研究的异质性,结果应谨慎解释,与一般人群相比,癌症生存期>12个月的患者房颤发生率没有显著增加。研究注册:开放科学框架- DOI: https://doi.org/10.17605/OSF.IO/APSYG。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Atrial fibrillation in cancer survivors - a systematic review and meta-analysis.

Atrial fibrillation in cancer survivors - a systematic review and meta-analysis.

Atrial fibrillation in cancer survivors - a systematic review and meta-analysis.

Background: Atrial fibrillation (AF) is a common cardiac complication during cancer treatment. It is unclear if cancer survivors have increased AF risk when compared to the population. AF screening is now recommended in patients ≥65 years, however there are no specific recommendations in the oncology population. We sought to compare the AF detection rate of cancer survivors compared to the general population.

Methods: We searched the Pubmed, Embase and Web of Science databases using search terms related to AF and cancer mapped to subject headings. We included English language studies, limited to adults > 18 years who were > 12 months post completion of cancer treatment. Using a random-effects model we calculated the overall AF detection rate. Meta-regression analysis was performed to assess for potential causes for study heterogeneity.

Results: Sixteen studies were included in the study. The combined AF detection rate amongst all the studies was 4.7% (95% C.I 4.0-5.4%), which equated to a combined annualised AF rate of 0.7% (95% C.I 0.1-0.98%). There was significant heterogeneity between studies (I2 = 99.8%, p < 0.001). In the breast cancer cohort (n = 6 studies), the combined annualised AF rate was 0.9% (95% C.I 0.1-2.3%), with significant heterogeneity (I2 = 99.9%, p < 0.001).

Conclusion: Whilst the results should be interpreted with caution due to study heterogeneity, AF rates in patients with cancer survival >12 months were not significantly increased compared to the general population.

Study registration: Open Science Framework - DOI: https://doi.org/10.17605/OSF.IO/APSYG .

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来源期刊
Cardio-oncology
Cardio-oncology Medicine-Cardiology and Cardiovascular Medicine
CiteScore
5.00
自引率
3.00%
发文量
17
审稿时长
7 weeks
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