应用于复杂超昼夜生物节律的分解分析:具有潜在计时功能的质膜NADH氧化酶的振荡活性。

Ken Foster, Nasim Anwar, Rhea Pogue, Dorothy M Morré, T W Keenan, D James Morré
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引用次数: 21

摘要

季节性分解分析应用于对质膜NADH氧化酶活性的振荡活性进行统计评估,其温度补偿周期为24 min。分解拟合用于验证循环振荡模式。三个测量值,即平均百分比误差(MAPE),周期性振荡的测量值,平均平均偏差(MAD),与拟合值的绝对平均偏差的测量值,以及平均标准差(MSD),与拟合值的标准差加上r平方的测量值和Henriksson-Merton p值用于评估精度。通过拟合数据的趋势线来进行分解,然后在必要时通过减去趋势分量来消除数据的趋势。然后,通过减去长度等于傅立叶分析确定的周期长度的中心移动平均线来平滑数据,无论有无去趋势。最后,将时间序列分解为循环分量和误差分量。这些发现不仅证实了主要振荡的周期性,而且还表明,在每个周期内,较小的中间波动也以可重复的模式重复出现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Decomposition Analyses Applied to a Complex Ultradian Biorhythm: The Oscillating NADH Oxidase Activity of Plasma Membranes Having a Potential Time-Keeping (Clock) Function.

Seasonal decomposition analyses were applied to the statistical evaluation of an oscillating activity for a plasma membrane NADH oxidase activity with a temperature compensated period of 24 min. The decomposition fits were used to validate the cyclic oscillatory pattern. Three measured values, average percentage error (MAPE), a measure of the periodic oscillation, mean average deviation (MAD), a measure of the absolute average deviations from the fitted values, and mean standard deviation (MSD), the measure of standard deviation from the fitted values plus R-squared and the Henriksson-Merton p value were used to evaluate accuracy.Decomposition was carried out by fitting a trend line to the data, then detrending the data if necessary, by subtracting the trend component. The data, with or without detrending, were then smoothed by subtracting a centered moving average of length equal to the period length determined by Fourier analysis. Finally, the time series were decomposed into cyclic and error components. The findings not only validate the periodic nature of the major oscillations but suggest, as well, that the minor intervening fluctuations also recur within each period with a reproducible pattern of recurrence.

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