DASH饮食对非酒精性脂肪性肝病肥胖成人动脉粥样硬化指数、促氧化-抗氧化平衡和肝脏脂肪变性的影响:一项双盲对照随机临床试验

IF 2.4 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Taghi Badali, Sara Arefhosseini, Farnaz Rooholahzadegan, Helda Tutunchi, Mehrangiz Ebrahimi-Mameghani
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引用次数: 0

摘要

背景:本临床试验旨在研究坚持饮食方法来停止高血压(DASH)饮食是否可以改善非酒精性脂肪性肝病(NAFLD)肥胖成人的脂质谱、促氧化-抗氧化平衡(PAB)和肝功能。方法:将62例NAFLD患者平均分为DASH组和低热量饮食组,疗程8周。在试验前后确定主要和次要结局。结果:40例患者完成了试验。干预后各组膳食饱和脂肪、硒、维生素A、E、体重、体质指数(BMI)、腰围(WC)组内差异均有统计学意义(PPP=0.008, P=0.019, P=0.003)。然而,各组间PAB水平无显著差异。此外,坚持DASH饮食比常规LCD饮食更有效地缓解肝脏脂肪变性(P=0.012)。结论:坚持DASH饮食似乎在改善肥胖、动脉粥样硬化和肝脏脂肪变性生物标志物方面更有效,但在改善氧化应激(OS)方面比常规LCD更有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The effect of DASH diet on atherogenic indices, pro-oxidant-antioxidant balance, and liver steatosis in obese adults with non-alcoholic fatty liver disease: A double-blind controlled randomized clinical trial.

The effect of DASH diet on atherogenic indices, pro-oxidant-antioxidant balance, and liver steatosis in obese adults with non-alcoholic fatty liver disease: A double-blind controlled randomized clinical trial.

The effect of DASH diet on atherogenic indices, pro-oxidant-antioxidant balance, and liver steatosis in obese adults with non-alcoholic fatty liver disease: A double-blind controlled randomized clinical trial.

The effect of DASH diet on atherogenic indices, pro-oxidant-antioxidant balance, and liver steatosis in obese adults with non-alcoholic fatty liver disease: A double-blind controlled randomized clinical trial.

Background: The present clinical trial aimed to examine whether adherence to Dietary Approaches to Stop Hypertension (DASH) diet could improve lipid profile, the Pro-oxidant-antioxidant balance (PAB) as well as liver function in obese adults with non-alcoholic fatty liver disease (NAFLD). Methods: Sixty two patients with NAFLD were equally allocated into either DASH or low-calorie diet (LCD) group for 8 weeks. The primary and secondary outcomes were determined before and after the trial. Results: Forty patients completed the trial. Significant within group differences were found in dietary saturated fat, selenium, vitamins A and E as well as body weight and body mass index (BMI) and waist circumference (WC) after the intervention (P<0.05). DASH diet showed greater significant change in systolic and diastolic blood pressure without significant differences between the groups after 8 weeks. Apart from serum high-density lipoprotein cholesterol (HDL-C) and triglyceride/HDL-C, greater reductions were found not only in serum lipids and atherogenic indices (P<0.05) but also in serum aspartate aminotransferase (AST), AST to platelet ratio index (APRI) and lipid accumulation product (LAP) in DASH group in comparison to control group (P=0.008, P=0.019 and P=0.003, respectively). Nevertheless, there was not any difference in PAB level between the groups. Furthermore, adherence to DASH diet was more effective in alleviating liver steatosis compared with usual LCD (P=0.012). Conclusion: Adherence to DASH diet appears to be more effective in improving obesity, atherogenic and liver steatosis biomarkers but not oxidative stress (OS) than usual LCD.

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来源期刊
Health Promotion Perspectives
Health Promotion Perspectives PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-
CiteScore
7.10
自引率
2.30%
发文量
27
审稿时长
13 weeks
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