乳香草中药制剂的疗效评价。改善认知障碍和阿尔茨海默病患者的认知和行为症状。

IF 0.8 Q4 PHARMACOLOGY & PHARMACY
Mahsa Panahishokouh, Maryam Noroozian, Fatemeh Mohammadian, Mahnaz Khanavi, Mahnaz Mirimoghaddam, Seyed Mehrdad Savar, Maryam Nikoosokhan, Hooshyar Honarmand, Niayesh Mohebbi
{"title":"乳香草中药制剂的疗效评价。改善认知障碍和阿尔茨海默病患者的认知和行为症状。","authors":"Mahsa Panahishokouh,&nbsp;Maryam Noroozian,&nbsp;Fatemeh Mohammadian,&nbsp;Mahnaz Khanavi,&nbsp;Mahnaz Mirimoghaddam,&nbsp;Seyed Mehrdad Savar,&nbsp;Maryam Nikoosokhan,&nbsp;Hooshyar Honarmand,&nbsp;Niayesh Mohebbi","doi":"10.4103/jrpp.jrpp_73_22","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the efficacy of an herbal formulation based on <i>Boswellia sacra</i> in improving cognitive and behavioral symptoms in patients with mild cognitive impairment (MCI) and mild-to-moderate stages of Alzheimer's disease (AD).</p><p><strong>Methods: </strong>A 3-month, parallel-group, placebo-controlled trial was implemented from October 2021 to April 2022. Patients with MCI and mild-to-moderate stages of AD aged above 50 years (<i>n</i> = 60; 40 women, 20 men) enrolled in the study using clinical diagnosis and a score of 10-30 on the mini-mental state examination (MMSE) test. They were assigned into two groups; one receiving a herbal formulation) include <i>B. sacra, Melissa officinalis, Piper longum, Cinnamomum verum, and Physalis alkekengi</i>) three times a day and the other receiving a placebo for 3 months. The main efficacy measures were the changes in cognitive domains based on the MMSE and changes in behavioral and psychiatric symptoms based on neuropsychiatric inventory (NPI) scores compared with baseline. Side effects were also recorded.</p><p><strong>Findings: </strong>Results of this study showed significant differences between the two groups after 3 months in terms of all the assessed variables, including the overall result of the mean score of MMSE and NPI tests (<i>P</i> ≤ 0.001). The herbal formulation had the most considerable effects on the domains of orientation, attention, working memory, delay recall, and language of the MMSE test.</p><p><strong>Conclusion: </strong>Herbal formulation based on <i>B. sacra</i> was significantly effective compared to a placebo in improving cognitive and behavioral symptoms in patients with MCI and mild-to-moderate AD.</p>","PeriodicalId":17158,"journal":{"name":"Journal of Research in Pharmacy Practice","volume":"11 3","pages":"91-98"},"PeriodicalIF":0.8000,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/16/1c/JRPP-11-91.PMC10252576.pdf","citationCount":"0","resultStr":"{\"title\":\"Evaluation of the Effectiveness of an Herbal Formulation of <i>Boswellia sacra Flueck</i>. In Improving Cognitive and Behavioral Symptoms in Patients with Cognitive Impairment and Alzheimer's Disease.\",\"authors\":\"Mahsa Panahishokouh,&nbsp;Maryam Noroozian,&nbsp;Fatemeh Mohammadian,&nbsp;Mahnaz Khanavi,&nbsp;Mahnaz Mirimoghaddam,&nbsp;Seyed Mehrdad Savar,&nbsp;Maryam Nikoosokhan,&nbsp;Hooshyar Honarmand,&nbsp;Niayesh Mohebbi\",\"doi\":\"10.4103/jrpp.jrpp_73_22\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aimed to assess the efficacy of an herbal formulation based on <i>Boswellia sacra</i> in improving cognitive and behavioral symptoms in patients with mild cognitive impairment (MCI) and mild-to-moderate stages of Alzheimer's disease (AD).</p><p><strong>Methods: </strong>A 3-month, parallel-group, placebo-controlled trial was implemented from October 2021 to April 2022. Patients with MCI and mild-to-moderate stages of AD aged above 50 years (<i>n</i> = 60; 40 women, 20 men) enrolled in the study using clinical diagnosis and a score of 10-30 on the mini-mental state examination (MMSE) test. They were assigned into two groups; one receiving a herbal formulation) include <i>B. sacra, Melissa officinalis, Piper longum, Cinnamomum verum, and Physalis alkekengi</i>) three times a day and the other receiving a placebo for 3 months. The main efficacy measures were the changes in cognitive domains based on the MMSE and changes in behavioral and psychiatric symptoms based on neuropsychiatric inventory (NPI) scores compared with baseline. Side effects were also recorded.</p><p><strong>Findings: </strong>Results of this study showed significant differences between the two groups after 3 months in terms of all the assessed variables, including the overall result of the mean score of MMSE and NPI tests (<i>P</i> ≤ 0.001). The herbal formulation had the most considerable effects on the domains of orientation, attention, working memory, delay recall, and language of the MMSE test.</p><p><strong>Conclusion: </strong>Herbal formulation based on <i>B. sacra</i> was significantly effective compared to a placebo in improving cognitive and behavioral symptoms in patients with MCI and mild-to-moderate AD.</p>\",\"PeriodicalId\":17158,\"journal\":{\"name\":\"Journal of Research in Pharmacy Practice\",\"volume\":\"11 3\",\"pages\":\"91-98\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2022-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/16/1c/JRPP-11-91.PMC10252576.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Research in Pharmacy Practice\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/jrpp.jrpp_73_22\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Research in Pharmacy Practice","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jrpp.jrpp_73_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

摘要

目的:本研究旨在评估以乳香草为基础的中药制剂对轻度认知障碍(MCI)和轻中度阿尔茨海默病(AD)患者认知和行为症状的改善效果。方法:从2021年10月至2022年4月进行为期3个月的平行组安慰剂对照试验。年龄在50岁以上的轻度认知障碍和轻中度AD患者(n = 60;40名女性,20名男性)通过临床诊断和10-30分的迷你精神状态检查(MMSE)测试加入了这项研究。他们被分成两组;一组每天服用三次草药制剂(包括骶骨B., Melissa officinalis, Piper longum, Cinnamomum verum和Physalis alkekengi),另一组服用安慰剂,持续3个月。主要疗效测量是基于MMSE的认知领域的变化,以及基于神经精神量表(NPI)评分的行为和精神症状与基线相比的变化。同时也记录了副作用。结果:本研究结果显示,两组在3个月后的所有评估变量,包括MMSE和NPI测试平均得分的总体结果,均有显著差异(P≤0.001)。中药配方对MMSE测试的定向、注意、工作记忆、延迟回忆和语言等领域的影响最为显著。结论:与安慰剂相比,以骶骨为基础的草药制剂在改善轻度认知损伤和轻度至中度AD患者的认知和行为症状方面显着有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Evaluation of the Effectiveness of an Herbal Formulation of <i>Boswellia sacra Flueck</i>. In Improving Cognitive and Behavioral Symptoms in Patients with Cognitive Impairment and Alzheimer's Disease.

Evaluation of the Effectiveness of an Herbal Formulation of Boswellia sacra Flueck. In Improving Cognitive and Behavioral Symptoms in Patients with Cognitive Impairment and Alzheimer's Disease.

Objective: This study aimed to assess the efficacy of an herbal formulation based on Boswellia sacra in improving cognitive and behavioral symptoms in patients with mild cognitive impairment (MCI) and mild-to-moderate stages of Alzheimer's disease (AD).

Methods: A 3-month, parallel-group, placebo-controlled trial was implemented from October 2021 to April 2022. Patients with MCI and mild-to-moderate stages of AD aged above 50 years (n = 60; 40 women, 20 men) enrolled in the study using clinical diagnosis and a score of 10-30 on the mini-mental state examination (MMSE) test. They were assigned into two groups; one receiving a herbal formulation) include B. sacra, Melissa officinalis, Piper longum, Cinnamomum verum, and Physalis alkekengi) three times a day and the other receiving a placebo for 3 months. The main efficacy measures were the changes in cognitive domains based on the MMSE and changes in behavioral and psychiatric symptoms based on neuropsychiatric inventory (NPI) scores compared with baseline. Side effects were also recorded.

Findings: Results of this study showed significant differences between the two groups after 3 months in terms of all the assessed variables, including the overall result of the mean score of MMSE and NPI tests (P ≤ 0.001). The herbal formulation had the most considerable effects on the domains of orientation, attention, working memory, delay recall, and language of the MMSE test.

Conclusion: Herbal formulation based on B. sacra was significantly effective compared to a placebo in improving cognitive and behavioral symptoms in patients with MCI and mild-to-moderate AD.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Research in Pharmacy Practice
Journal of Research in Pharmacy Practice PHARMACOLOGY & PHARMACY-
自引率
0.00%
发文量
8
审稿时长
21 weeks
期刊介绍: The main focus of the journal will be on evidence-based drug-related medical researches (with clinical pharmacists’ intervention or documentation), particularly in the Eastern Mediterranean region. However, a wide range of closely related issues will be also covered. These will include clinical studies in the field of pharmaceutical care, reporting adverse drug reactions and human medical toxicology, pharmaco-epidemiology and toxico-epidemiology (poisoning epidemiology), social aspects of pharmacy practice, pharmacy education and economic evaluations of treatment protocols (e.g. cost-effectiveness studies). Local reports of medication utilization studies at hospital or pharmacy levels will only be considered for peer-review process only if they have a new and useful message for the international pharmacy practice professionals and readers.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信