复方口服避孕药治疗寻常性痤疮的研究进展。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-06-01 DOI:10.1080/13625187.2023.2197539

Giovanni Grandi, Gloria Guariglia, Fabio Facchinetti

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引用次数: 1

摘要

美国食品和药物管理局(fda)和欧洲药品管理局(EMA)批准使用含有乙炔雌二醇(EE)和诺格估计(NGM)的三相联合口服避孕药(COC)治疗需要有效避孕的妇女的寻常性痤疮。COCs可以靶向皮脂生成，也可能在减少毛囊角化过度中发挥作用。结果:本综述提出了在这种情况下使用抗雄激素黄体酮(如NGM)的具体优势，包括EMA确定的COCs情况下静脉血栓形成风险最低，与非常满意的周期控制相关。对已发表数据的汇总分析结果(n = 163 vs. n = 161治疗对象)表明，在炎症病变(从19.0减少到8.2)、粉刺(从35.2减少到17.7)和总病变(从54.3减少到25.9)计数方面，与安慰剂相比，显着效果减少了50%以上。结论:选择EE/NGM三期联合治疗寻常性痤疮，可单独或联合不同靶向药物治疗，是一种可参考、高效、易用、安全的治疗方法。

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The role of combined oral contraceptives containing norgestimate for acne vulgaris treatment: a review.

Introduction: Both Food and Drugs Administration and European Medicine Agency (EMA) approve the use of a triphasic combined oral contraceptive (COC) containing ethinyl-oestradiol (EE) and norgestimate (NGM) for acne vulgaris treatment in women requiring an effective contraception. COCs can target sebum production and may also play a role in decreasing follicular hyperkeratinisation.

Results: Specific advantages of the use of an anti-androgenic progestin such as NGM in this condition are presented in this review, including the lowest venous thrombosis risk in the COCs scenario, as established by the EMA, associated with a very satisfactory cycle control. The results of aggregate analysis of published data (n = 163 vs. n = 161 treated subjects) demonstrate a significant effect in comparison with the placebo of a greater than 50% reduction, in terms of inflammatory lesions (from 19.0 to 8.2), comedones (from 35.2 to 17.7) and total lesions (from 54.3 to 25.9) count.

Conclusions: The choice of a triphasic combination of EE/NGM seems a referenced, highly effective, easy-to-use and safe therapeutic approach for acne vulgaris, alone or in combination with different targeted drugs.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.