Priyanshi S Akbari, Yusra Hassan, Lisa Archibald, Tania Tajik, Kaitlin Dunn, Mara Berris, Jenna Smith-Turchyn
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引用次数: 0
摘要
目的：确定在化疗期间进行体育锻炼（PA）的癌症幸存者与未进行体育锻炼的癌症幸存者相比，认知功能水平是否有所提高。研究方法：检索从开始到 2020 年 2 月 4 日的电子数据库（Ovid MEDLINE、Embase、CINAHL、PsycINFO、AMED）。筛选出的定量研究评估了任何癌症类型的成人在接受 PA 化疗的同时的认知结果。采用 Cochrane's RoB 2、ROBINS-I 和 Newcastle-Ottawa 等量表对偏倚风险进行评估。使用标准化平均差 (SMD) 进行了荟萃分析。研究结果22 项研究（15 项随机对照试验和 7 项非随机对照试验）符合纳入标准。荟萃分析表明，与常规护理相比，联合阻力训练和有氧训练对社会认知有微小但具有统计学意义的影响（SMD 0.23 [95% CI: 0.04, 0.42], p = 0.020）。结论抗阻力运动和有氧运动相结合可能对接受化疗的癌症幸存者的社会认知能力有益。由于所纳入研究的偏倚风险较高且证据质量较低，我们建议进一步调查以支持这些发现，并提出具体的PA建议。
Effect of Physical Activity During Chemotherapy on Cognitive Function in Cancer Survivors: A Systematic Review and Meta-Analysis.
Purpose: To determine if cancer survivors who perform physical activity (PA) during chemotherapy have improved levels of cognitive function compared to those who do not. Method: E-databases (Ovid MEDLINE, Embase, CINAHL, PsycINFO, AMED) were searched from inception to February 4, 2020. Quantitative studies that assessed cognitive outcomes for adults with any cancer type who received chemotherapy concurrent with PA were selected. Risk of bias was assessed using Cochrane's RoB 2, ROBINS-I, and Newcastle-Ottawa scales. A meta-analysis was performed using standardized mean difference (SMD). Results: Twenty-two studies (15 randomized controlled trials [RCTs] and 7 non-RCTs) met the inclusion criteria. The meta-analysis demonstrated that combined resistance and aerobic training had a small yet statistically significant effect on social cognition compared to usual care (SMD 0.23 [95% CI: 0.04, 0.42], p = 0.020). Conclusions: Combined resistance and aerobic exercise may benefit social cognition in cancer survivors undergoing chemotherapy. Due to high risk of bias and low quality of evidence of included studies, we recommend further investigation to support these findings and make specific PA recommendations.
期刊介绍：
Physiotherapy Canada is the official, scholarly, refereed journal of the Canadian Physiotherapy Association (CPA), giving direction to excellence in clinical science and reasoning, knowledge translation, therapeutic skills and patient-centred care.
Founded in 1923, Physiotherapy Canada meets the diverse needs of national and international readers and serves as a key repository of inquiries, evidence and advances in the practice of physiotherapy.
Physiotherapy Canada publishes the results of qualitative and quantitative research including systematic reviews, meta analyses, meta syntheses, public/health policy research, clinical practice guidelines, and case reports. Key messages, clinical commentaries, brief reports and book reviews support knowledge translation to clinical practice.
In addition to delivering authoritative, original scientific articles and reports of significant clinical studies, Physiotherapy Canada’s editorials and abstracts are presented in both English and French, expanding the journal’s reach nationally and internationally. Key messages form an integral part of each research article, providing a succinct summary for readers of all levels. This approach also allows readers to quickly get a feel for ‘what is already known’ and ‘what this study adds to’ the subject.
Clinician’s commentaries for key articles assist in bridging research and practice by discussing the article’s impact at the clinical level. The journal also features special themed series which bring readers up to date research supporting evidence-informed practice.
The Canadian Physiotherapy Association (CPA) is the national professional association representing almost 15,000 members distributed throughout all provinces and territories. CPA’s mission is to provide leadership and direction to the physiotherapy profession, foster excellence in practice, education and research, and promote high standards of health in Canada.
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