J L Alonso Bilbao, A de Arriba Fernández, A Espiñeira Francés, A Cabeza Mora, A Gutiérrez Pérez, M A Díaz Barreiros
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引用次数: 0
摘要
目的:分析2021-2022年流感疫苗接种状况与SARS-CoV-2病毒感染患者流感和SARS-CoV-2合并感染的频率、病程(死亡风险、住院和重症监护入院)的差异。方法:以人群为基础的观察性回顾性研究，对2021年6月1日至2022年2月28日在大加那利岛诊断为COVID-19的19850例患者进行队列研究。结果:共有1,789名(9%)被诊断为COVID-19的患者接受了流感疫苗接种。13676人(68.9%)接种了全程疫苗。在2021年6月1日至2022年2月28日期间，记录了8例流感和COVID-19合并感染病例。高血压(18.5%)、哮喘(12.8%)和糖尿病(7.2%)是最常见的合并症。死亡147例(0.7%)。老年患者([OR] 1.11 95% CI 1.09-1.13)和癌症患者([OR] 4.21 95% CI 2.58-6.89)死于COVID-19的风险更高(结论:年龄、男性和癌症是死亡的独立预后因素。三剂SARS-CoV-2疫苗和流感疫苗在预防covid -19相关死亡和住院方面非常有效。这些发现表明，流感疫苗可以帮助控制流感大流行。
[Epidemiological study on the impact of influenza vaccination on the clinical course of patients with COVID-19 and co-infection by both viruses in Gran Canaria, Spain].
Objective: To analyze the frequency of influenza and SARS-CoV-2 co-infections, as well as the differences in the course of disease (risk of mortality, hospital and intensive care admissions) in patients infected with the SARS-CoV-2 virus in relation to flu vaccination status in the 2021-2022 season.
Methods: Population-based observational retrospective study in a cohort of 19,850 patients diagnosed with COVID-19 between June 1, 2021 and February 28, 2022 on the island of Gran Canaria.
Results: A total of 1,789 patients (9%) diagnosed with COVID-19 had received flu vaccinations. 13,676 people (68.9%) had a full course of COVID-19 vaccinations. In the period between June 1, 2021 and February 28, 2022, 8 cases of flu and COVID-19 coinfection were recorded. Hypertension (18.5%), asthma (12.8%) and diabetes (7.2%) were the most frequent comorbidities. There were 147 deaths (0.7%). Older patients ([OR] 1.11 95% CI 1.09-1.13) and people with cancer ([OR] 4.21 95% CI 2.58-6.89) had a higher risk of dying from COVID-19 (p<0.05). Female sex was noted as a protective factor ([OR] 0.61 95% CI 0.40-0.92).
Conclusions: Old age, male sex and cancer were independent prognostic factors for mortality. Three doses of SARS-CoV-2 vaccines and influenza vaccines were highly effective in preventing COVID-19-related deaths and hospital admissions. These findings suggest that flu vaccination can help control the pandemic.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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