糖尿病中的生物活性维生素和表观遗传修饰：透视。

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM

Current diabetes reviews Pub Date : 2024-01-01 DOI:10.2174/1573399819666230330124035

Mihnea-Alexandru Găman, Elena-Codruța Cozma, Bahadar S Srichawla, Matei-Alexandru Cozma, Hamed Kord Varkaneh, Yongfeng Chen, Amelia Maria Găman, Camelia Cristina Diaconu

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引用次数: 0

摘要

糖尿病是一种复杂的代谢性疾病，与表观遗传变化有关。饮食模式等外部因素会导致体内微量营养素和宏量营养素的不平衡。因此，生物活性维生素可能会通过以下几种途径影响表观遗传机制：参与控制基因表达和蛋白质合成，在甲基代谢或 DNA 和组蛋白甲基化过程中充当辅酶和辅助因子。在此，我们将从生物活性维生素与糖尿病表观遗传修饰的相关性角度进行阐述。

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Bioactive Vitamins and Epigenetic Modifications in Diabetes: A Perspective.

Diabetes is a complex metabolic disease that has been associated with epigenetic changes. External factors such as dietary patterns can induce an imbalance in the pools of micronutrients and macronutrients in the body. Consequently, bioactive vitamins may influence epigenetic mechanisms via several pathways: involvement in the control of gene expression, and in protein synthesis, by acting as coenzymes and co-factors in the metabolism of methyl groups or methylation of DNA and histones. Herein, we present a perspective on the relevance of bioactive vitamins in the epigenetic modifications that occur in diabetes.

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来源期刊

Current diabetes reviews ENDOCRINOLOGY & METABOLISM-

CiteScore

6.30

自引率

0.00%

发文量

158

期刊介绍： Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.