[自噬调节阻塞性睡眠呼吸暂停多器官损伤及其相关机制]。

N Dong, H M Yue, X Wang, R J Lyu, Y He
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引用次数: 0

摘要

阻塞性睡眠呼吸暂停是一种与睡眠有关的缺氧/再氧合综合征,可导致心脑血管疾病、糖脂代谢、神经系统甚至多器官损伤,严重威胁人体健康。自噬是真核细胞依靠溶酶体途径降解异常蛋白和细胞器,维持细胞内环境的稳态,实现自我更新的过程。许多研究发现,阻塞性睡眠呼吸暂停对心肌、海马、肾脏等器官造成损害,其机制可能与自噬有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Autophagy regulates multiple organ injury in obstructive sleep apnea and its related mechanisms].

Obstructive sleep apnea is a sleep-related hypoxia/reoxygenation syndrome that can lead to cardiovascular and cerebrovascular diseases, glucose and lipid metabolism, nervous system and even multiple organ damage, and is a serious threat to human health. Autophagy is a process by which eukaryotic cells rely on the lysosome pathway to degrade abnormal proteins and organelles, maintain homeostasis of intracellular environment and achieve self-renewal. Many studies have found that obstructive sleep apnea causes damage to myocardial, hippocampus, kidney and other organs, and its mechanism may be related to autophagy.

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