溶瘤性寨卡病毒:胶质母细胞瘤治疗的新选择。

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

DNA and cell biology Pub Date : 2023-06-01 DOI:10.1089/dna.2022.0375

Chao Zhou, Qi Chen, Yun Chen, Cheng-Feng Qin

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引用次数: 4

摘要

胶质母细胞瘤(GBM)是侵袭性最强的脑肿瘤之一，复发率高，迫切需要有效的治疗。GBM干细胞(GSCs)有助于GBM复发以及对放疗和化疗的治疗抗性。几种溶瘤病毒(OVs)已经开发出来，并在临床试验中得到验证，对GBM具有良好的安全性和有效性。最近，寨卡病毒(ZIKV)，一种蚊媒黄病毒，被证明优先靶向和杀死GSCs，并在临床前模型中显示出治疗GBM的良好效果。在这篇综述中，我们总结了已知的用于治疗GBM的OVs，并强调了溶瘤性ZIKV临床开发的主要优势和存在的挑战。

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Oncolytic Zika Virus: New Option for Glioblastoma Treatment.

Glioblastoma (GBM) is one of the most aggressive brain tumors and has a high recurrence rate, and effective treatment is urgently needed. GBM stem cells (GSCs) contribute to GBM recurrence as well as therapeutic resistance to radiation and chemotherapy. Several oncolytic viruses (OVs) have been developed and validated in clinical trials with favorable safety profiles and efficacy against GBM. Recently, Zika virus (ZIKV), a mosquito-borne flavivirus, was shown to preferentially target and kill GSCs and showed promising therapeutic effects in treating GBM in preclinical models. In this review, we summarize the known OVs for the treatment of GBM and highlight the major advantages and existing challenges for the clinical development of oncolytic ZIKV.

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来源期刊

DNA and cell biology 生物-生化与分子生物学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

1.5 months

期刊介绍： DNA and Cell Biology delivers authoritative, peer-reviewed research on all aspects of molecular and cellular biology, with a unique focus on combining mechanistic and clinical studies to drive the field forward. DNA and Cell Biology coverage includes: Gene Structure, Function, and Regulation Gene regulation Molecular mechanisms of cell activation Mechanisms of transcriptional, translational, or epigenetic control of gene expression Molecular Medicine Molecular pathogenesis Genetic approaches to cancer and autoimmune diseases Translational studies in cell and molecular biology Cellular Organelles Autophagy Apoptosis P bodies Peroxisosomes Protein Biosynthesis and Degradation Regulation of protein synthesis Post-translational modifications Control of degradation Cell-Autonomous Inflammation and Host Cell Response to Infection Responses to cytokines and other physiological mediators Evasive pathways of pathogens.