改进与实体性非甲状腺癌相关的甲状腺功能减退症的个性化诊断、治疗和开发。

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Maria V Deligiorgi, Dimitrios T Trafalis
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引用次数: 0

摘要

由于甲状腺激素(TH)在癌症中的双重作用-促进与抑制-以及甲状腺功能减退本身的复杂性,癌症背景下的甲状腺功能减退是一个令人困惑的实体。本文综述了治疗实体性非甲状腺癌患者甲状腺功能减退的个体化治疗方法,重点介绍了当前的挑战、未满足的需求和未来的展望。主要电子数据库的检索时间为2011年1月至2022年3月。完善这种个性化方法的里程碑是及时诊断,适当的甲状腺激素替代和开发干预措施和/或药物药物来利用甲状腺功能减退,或者相反,将甲状腺激素替代作为抗癌策略。进一步阐明促甲状腺激素在癌症中的双重作用-特别是对促甲状腺激素信号与癌症特征的干扰-有望为决策和优化患者选择提供信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Refining personalized diagnosis, treatment and exploitation of hypothyroidism related to solid nonthyroid cancer.

Hypothyroidism in the setting of cancer is a puzzling entity due to the dual role of the thyroid hormones (TH) in cancer - promoting versus inhibitory - and the complexity of the hypothyroidism itself. The present review provides a comprehensive overview of the personalized approach to hypothyroidism in patients with solid nonthyroid cancer, focusing on current challenges, unmet needs and future perspectives. Major electronic databases were searched from January 2011 until March 2022. The milestones of the refinement of such a personalized approach are prompt diagnosis, proper TH replacement and development of interventions and/or pharmaceutical agents to exploit hypothyroidism or, on the contrary, TH replacement as an anticancer strategy. Further elucidation of the dual role of TH in cancer - especially of the interference of TH signaling with the hallmarks of cancer - is anticipated to inform decision-making and optimize patient selection.

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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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