揭示帕金森病和肺癌之间的基因联系。

IF 2.9 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Yong Qi Leong, Rhun Yian Koh, Soi Moi Chye, Khuen Yen Ng
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引用次数: 0

摘要

流行病学研究越来越多的证据表明帕金森病(PD)和肺癌之间呈负相关。PD和肺癌都是老年性疾病,这两种疾病有一些共同的遗传决定因素。一些pd相关基因,包括α突触核蛋白(SNCA)、pten诱导的激酶1 (PINK1)、帕金、帕金森病相关脱糖酶(DJ-1)、富含亮氨酸的重复激酶2 (LRRK2)、F-box蛋白7 (FBXO7)和泛素c端水解酶L1 (UCHL1)在肺癌患者中表达改变。这表明某些pd相关基因可能在赋予抗癌作用方面很重要。本文旨在介绍这些基因的生理功能,并讨论这些pd相关基因在肺癌中的可能作用。了解这些基因在肺癌进展中的作用可能对确定肺癌的新治疗靶点具有重要意义。旨在改变这些基因表达的基因疗法可以用于未来的抗癌治疗。因此,研究这些基因在肺癌中的作用也可能有助于了解它们在PD发病机制中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Unravelling the genetic links between Parkinson's disease and lung cancer.

Increase evidence from epidemiological studies have shown an inverse association between Parkinson's disease (PD) and lung cancer. PD and lung cancer are both geriatric diseases, where these two diseases are sharing some common genetic determinants. Several PD-associated genes including alpha synuclein (SNCA), PTEN-induced kinase 1 (PINK1), parkin, parkinsonism associated deglycase (DJ-1), leucine-rich repeat kinase 2 (LRRK2), F-box protein 7 (FBXO7) and ubiquitin C-terminal hydrolase L1 (UCHL1) were reported to have altered expressions in lung cancer patients. This indicates that certain PD-associated genes might be important in conferring anticancer effects. This review aims to depict the physiological functions of these genes, and discuss the putative roles of these PD-associated genes in lung cancer. The understanding of the roles of these genes in the lung cancer progression might be important in the identification of new treatment targets for lung cancer. Gene therapy that aims to alter the expressions of these genes could be developed for future anticancer therapy. As a result, studying the roles of these genes in lung cancer may also help to understand their involvements as well as their roles in the pathogenesis of PD.

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来源期刊
Biological Chemistry
Biological Chemistry 生物-生化与分子生物学
CiteScore
7.20
自引率
0.00%
发文量
63
审稿时长
4-8 weeks
期刊介绍: Biological Chemistry keeps you up-to-date with all new developments in the molecular life sciences. In addition to original research reports, authoritative reviews written by leading researchers in the field keep you informed about the latest advances in the molecular life sciences. Rapid, yet rigorous reviewing ensures fast access to recent research results of exceptional significance in the biological sciences. Papers are published in a "Just Accepted" format within approx.72 hours of acceptance.
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