干扰素受体1-56C/T基因多态性与肺结节病遗传易感性关系的横断面研究

IF 1.1 4区 医学 Q4 Medicine
Serdar Kaymaz, Murat Kavas, Aydın Demiray, Uğur Karasu, Veli Çobankara, Sibel Boğa
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引用次数: 1

摘要

目的:探讨干扰素受体1 (IFNGR1)多态性与肺结节病易感性的关系。患者和方法:共纳入55例患者(男性13例,女性42例;平均年龄:46.5±9.1岁;年龄22 - 66岁),有肺结节病和28名健康对照(男性6人,女性22人;平均年龄:43.9±5.9岁;年龄从22岁到60岁不等)。聚合酶链反应用于参与者的基因分型,以确定单核苷酸多态性。Hardy-Weinberg平衡被认为是检测基因分型错误的重要工具。采用logistic回归分析比较患者和对照组的等位基因和基因型频率。结果:检测的IFNGR1单核苷酸多态性(rs2234711)与肺结节病无相关性(p>0.05)。根据临床特征、实验室和影像学特征进行分类分析,IFNGR1 (rs2234711)多态性检测与上述特征无相关性(p>0.05)。结论:本研究结果显示,检测到的IFNGR1基因多态性(rs2234711)与肺结节病无关。需要更全面的研究来验证我们的结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Investigation of the relationship between interferon-gamma receptor 1-56C/T gene polymorphism and genetic susceptibility to lung sarcoidosis: A cross-sectional study.

Objectives: This study aims to investigate the relationship between the interferon-gamma receptor 1 (IFNGR1) polymorphism and susceptibility to lung sarcoidosis.

Patients and methods: The study included a total of 55 patients (13 males, 42 females; mean age: 46.5±9.1 years; range, 22 to 66 years) with lung sarcoidosis and 28 healthy controls (6 males, 22 females; mean age: 43.9±5.9 years; range 22 to 60 years) selected from the Turkish population. The polymerase chain reaction was used for genotyping of participants to determine single-nucleotide polymorphisms. Hardy-Weinberg equilibrium, which is considered an important tool for detecting genotyping errors, was tested. Allele and genotype frequencies of patients and controls were compared using logistic regression analysis.

Results: The analyses showed no correlation between the tested IFNGR1 single-nucleotide polymorphism (rs2234711) and lung sarcoidosis (p>0.05). The categorization analysis according to the clinical features, laboratory, and radiographic characteristics showed no correlation between the tested polymorphism of IFNGR1 (rs2234711) and these characteristics (p>0.05).

Conclusion: The results of the study showed that the tested gene polymorphism (rs2234711) of IFNGR1 was not associated with lung sarcoidosis. More comprehensive studies are needed to verify our results.

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来源期刊
Archives of rheumatology
Archives of rheumatology Medicine-Rheumatology
CiteScore
2.00
自引率
9.10%
发文量
15
期刊介绍: The Archives of Rheumatology is an official journal of the Turkish League Against Rheumatism (TLAR) and is published quarterly in March, June, September, and December. It publishes original work on all aspects of rheumatology and disorders of the musculoskeletal system. The priority of the Archives of Rheumatology is to publish high-quality original research articles, especially in inflammatory rheumatic disorders. In addition to research articles, brief reports, reviews, editorials, letters to the editor can also be published. It is an independent peer-reviewed international journal printed in English. Manuscripts are refereed by a "double-blind peer-reviewed" process for both referees and authors. Editorial Board of the Archives of Rheumatology works under the principles of The World Association of Medical Editors (WAME), the International Council of Medical Journal Editors (ICMJE), and Committee on Publication Ethics (COPE).
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