分析1423例阑尾切除标本中的阑尾肿瘤:一项来自单一机构的10年回顾性队列研究。

IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Ahmet Rencuzogullari, Cihan Atar, Ugur Topal, İbrahim Coğal, Ahmet Gokhan Saritas, Orcun Yalav, Kubilay Dalci, İsmail Cem Eray
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引用次数: 0

摘要

目的:本研究旨在揭示阑尾肿瘤的发病率、临床病理和肿瘤预后。方法:这是一项来自单一机构的回顾性队列研究。纳入2011年1月至2021年1月间病理诊断为恶性的阑尾切除术患者,按病理分型分组。比较两组的临床、病理和肿瘤学结果。结果:1423例阑尾切除术患者中肿瘤发生率为2.38% (n=34)。其中56% (n=19)为女性。整个队列的中位年龄为55.5岁(范围:13-106岁)。在队列中,根据美国阑尾肿瘤联合委员会的分类,神经内分泌肿瘤粘液囊腺瘤腺癌和低级别阑尾粘液瘤的发生率分别为32.3% (n=11)、26.4% (n=9)、26.4% (n=9)和14.7% (n=5)。神经内分泌肿瘤患者(中位年龄:35岁)较其他组年轻(p=0.021)。66.7% (n=6)的腺癌患者和27.3% (n=3)的神经内分泌肿瘤患者进行了二次补充手术。所有需要二次手术的神经内分泌肿瘤患者均行右半结肠切除术,3例腺癌患者行右半结肠切除术,3例腺癌患者行细胞减少术和腹腔内高温化疗。中位随访44.4个月(95%可信区间:18.6-70.1)后,阑尾腺癌患者的平均生存率为55%,而神经内分泌肿瘤患者的平均生存率为100%。结论:阑尾肿瘤虽罕见,但仍是导致死亡的重要原因。与其他肿瘤相比,阑尾腺癌的预后较差。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of appendiceal neoplasms in 1,423 appendectomy specimens: a 10-year retrospective cohort study from a single institution.

Objective: This study aimed to reveal the incidence, clinicopathological, and oncological outcomes of appendiceal neoplasms.

Methods: This is a retrospective cohort study from a single institution. Patients with a pathological diagnosis of malignancy who underwent appendectomy between January 2011 and 2021 were included in the study, and groups were formed according to pathological type. Clinical, pathological, and oncological results were compared in these groups.

Results: The incidence of neoplasia was 2.38% (n=34) in a cohort of 1,423 appendectomy cases. Of the cases, 56% (n=19) were female. The median age in the entire cohort was 55.5 (range: 13-106) years. In the cohort, the rate of neuroendocrine tumor mucinous cystadenoma adenocarcinoma, and low-grade appendiceal mucinous neoplasm, according to the American Joint Committee on Cancer classification of appendiceal neoplasms, was 32.3% (n=11), 26.4% (n=9), 26.4% (n=9), and 14.7% (n=5), respectively. Neuroendocrine tumor patients (median age: 35 years) were younger than the other groups (p=0.021). Secondary complementary surgery was performed in 66.7% (n=6) of adenocarcinoma patients and 27.3% (n=3) of neuroendocrine tumor patients. Right hemicolectomy was performed in all neuroendocrine tumor patients requiring secondary surgery, while right hemicolectomy was performed in three adenocarcinoma patients and cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in three adenocarcinoma patients. After a median follow-up of 44.4 months (95% confidence interval: 18.6-70.1), the mean survival rate was 55% in appendiceal adenocarcinoma patients compared to 100% in neuroendocrine tumor patients.

Conclusion: Appendiceal neoplasms are rare but remain an important cause of mortality. Appendiceal adenocarcinomas are associated with poorer oncological outcomes compared to other neoplasms.

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来源期刊
CiteScore
2.20
自引率
0.00%
发文量
276
审稿时长
12 weeks
期刊介绍: A Revista da Associação Médica Brasileira (RAMB), editada pela Associação Médica Brasileira, desde 1954, tem por objetivo publicar artigos que contribuam para o conhecimento médico.
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