高强度辐射(x射线)对医院放射技师的遗传毒性影响

IF 2.3 4区 医学 Q3 ENVIRONMENTAL SCIENCES
Haripriya Kuchi Bhotla, Balamuralikrishnan Balasubramanian, Kannan R. R. Rengasamy, Vijaya Anand Arumugam, Karthick Kumar Alagamuthu, Vadivalagan Chithravel, Aditi Chaudhary, Amer M. Alanazi, Manikantan Pappuswamy, Arun Meyyazhagan
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引用次数: 0

摘要

医学领域最近的技术进步增加了在诊断或治疗特定疾病时将人类暴露于高强度波长辐射(如x射线和伽马射线)的可能性。这些辐射会有意或无意地引起受照射人群的核苷酸变化和染色体改变。特别是在重症监护病房工作的技术人员,经常使用放射检查来确定疾病。目前的研究使用通用的细胞遗传学工具,如微核测定(MN)、姐妹染色单体交换和彗星测定,观察了在工作场所暴露于高强度辐射(x射线)的临床医生的染色体异常(CA)等遗传损伤。这项研究在100名来自腹部扫描、胸部扫描、颅骨和骨科或骨骼扫描部门的从业人员以及年龄匹配的健康对照者之间进行。我们观察到,随着年龄和工作暴露时间的增加,骨科和胸科从业人员MN和CA的发生率略高于其他部门(p < 0.05)。我们的结果强调在临床和医院辐射实验室采取额外的预防措施,以保护从业人员。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Genotoxic repercussion of high-intensity radiation (x-rays) on hospital radiographers

Genotoxic repercussion of high-intensity radiation (x-rays) on hospital radiographers

Recent technological advances in the medical field have increased the plausibility of exposing humans to high-intensity wavelength radiations like x-rays and gamma rays while diagnosing or treating specific medical maladies. These radiations induce nucleotide changes and chromosomal alterations in the exposed population, intentionally or accidentally. A radiological investigation is regularly used in identifying the disease, especially by the technicians working in intensive care units. The current study observes the genetic damages like chromosomal abnormalities (CA) in clinicians who are occupationally exposed to high-intensity radiations (x-rays) at their workplaces using universal cytogenetic tools like micronucleus assay (MN), sister chromatid exchange and comet assay. The study was conducted between 100 exposed practitioners from the abdominal scanning, chest scanning, cranial and orthopedic or bone scanning department and age-matched healthy controls. We observed a slightly higher rate of MN and CA (p < .05) in orthopedic and chest department practitioners than in other departments concerning increasing age and duration of exposure at work. Our results emphasize taking extra precautionary measures in clinical and hospital radiation laboratories to protect the practitioners.

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来源期刊
CiteScore
5.40
自引率
10.70%
发文量
52
审稿时长
12-24 weeks
期刊介绍: Environmental and Molecular Mutagenesis publishes original research manuscripts, reviews and commentaries on topics related to six general areas, with an emphasis on subject matter most suited for the readership of EMM as outlined below. The journal is intended for investigators in fields such as molecular biology, biochemistry, microbiology, genetics and epigenetics, genomics and epigenomics, cancer research, neurobiology, heritable mutation, radiation biology, toxicology, and molecular & environmental epidemiology.
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