Saira Saleem, Iffat Aleem, Muhammad Zeshan, Muhammad Abu Bakar, Aribah Atiq, Muhammad Tahseen, Mohammad Tariq Mahmood, Sadia Hassan, Aamir Ali Syed, Mudassar Hussain, Asad Hayat Ahmad, Shahid Khattak, Muhammed Aasim Yusuf
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BMI (Kg/m<sup>2</sup>) was classified according to the World Health Organization criteria as underweight (<18.5 Kg/m<sup>2</sup>), normal weight (18.5-24.9 Kg/m<sup>2</sup>) and overweight (≥25 Kg/m<sup>2</sup>).</p><p><strong>Results: </strong>Among 236 participants, 99 (41.9%) belonged to the NC group, and 137 (58.1 %) participants had CC Overall, participants included 74 women and 162 men aged 20-85 years (mean ± SD; 49.9 ± 14.9). Notably, 46.0% of cancer patients had a family history of cancer. There was a direct relationship between CC with abnormal BMI (underweight and overweight), positive smoking history and positive family history of cancer.</p><p><strong>Conclusion: </strong>Being underweight or overweight is a potential risk factor for CC patients. The overall survival in patients with CC is clinically associated with lifestyle choices before CC diagnosis. A balanced diet, walking and other forms of exercise should be strongly recommended to the community and those undergoing screening colonoscopy.</p>","PeriodicalId":73631,"journal":{"name":"Journal of cancer & allied specialties","volume":"8 2","pages":"477"},"PeriodicalIF":0.0000,"publicationDate":"2022-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9a/37/JCAS-8-477.PMC10187604.pdf","citationCount":"0","resultStr":"{\"title\":\"Body Mass Index and Other Risk Factors Effects on Colon Cancer Prognosis in Pakistan.\",\"authors\":\"Saira Saleem, Iffat Aleem, Muhammad Zeshan, Muhammad Abu Bakar, Aribah Atiq, Muhammad Tahseen, Mohammad Tariq Mahmood, Sadia Hassan, Aamir Ali Syed, Mudassar Hussain, Asad Hayat Ahmad, Shahid Khattak, Muhammed Aasim Yusuf\",\"doi\":\"10.37029/jcas.v8i2.477\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Asian developing countries share the burden of colorectal cancer (CRC) with rising mortality rates. This prospective study aims to apprehend the clinical relevance of age, gender, lifestyle choices (dietary habits and addiction) and body mass index (BMI) to the occurrence and progression of colon cancer (CC).</p><p><strong>Methods: </strong>A cohort of non-cancer (NC) and CC patients of South-Central Asian origin registered for screening colonoscopy or surgery at Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH and RC), Lahore, Pakistan, from 2015 to 2020 was identified. BMI (Kg/m<sup>2</sup>) was classified according to the World Health Organization criteria as underweight (<18.5 Kg/m<sup>2</sup>), normal weight (18.5-24.9 Kg/m<sup>2</sup>) and overweight (≥25 Kg/m<sup>2</sup>).</p><p><strong>Results: </strong>Among 236 participants, 99 (41.9%) belonged to the NC group, and 137 (58.1 %) participants had CC Overall, participants included 74 women and 162 men aged 20-85 years (mean ± SD; 49.9 ± 14.9). Notably, 46.0% of cancer patients had a family history of cancer. There was a direct relationship between CC with abnormal BMI (underweight and overweight), positive smoking history and positive family history of cancer.</p><p><strong>Conclusion: </strong>Being underweight or overweight is a potential risk factor for CC patients. The overall survival in patients with CC is clinically associated with lifestyle choices before CC diagnosis. A balanced diet, walking and other forms of exercise should be strongly recommended to the community and those undergoing screening colonoscopy.</p>\",\"PeriodicalId\":73631,\"journal\":{\"name\":\"Journal of cancer & allied specialties\",\"volume\":\"8 2\",\"pages\":\"477\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-08-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9a/37/JCAS-8-477.PMC10187604.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of cancer & allied specialties\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37029/jcas.v8i2.477\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of cancer & allied specialties","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37029/jcas.v8i2.477","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
导言：亚洲发展中国家共同承受着结直肠癌（CRC）的负担，其死亡率也在不断上升。这项前瞻性研究旨在了解年龄、性别、生活方式（饮食习惯和嗜好）和体重指数（BMI）与结肠癌（CC）发生和发展的临床相关性：方法：对 2015 年至 2020 年期间在巴基斯坦拉合尔肖卡特-卡努姆纪念癌症医院和研究中心（SKMCH and RC）登记接受结肠镜检查或手术的中南亚裔非癌症（NC）和 CC 患者进行了队列识别。体重指数（Kg/m2）根据世界卫生组织的标准分为体重不足（2）、体重正常（18.5-24.9 Kg/m2）和超重（≥25 Kg/m2）：在 236 名参与者中，99 人（41.9%）属于 NC 组，137 人（58.1%）患有 CC 总体而言，参与者包括 74 名女性和 162 名男性，年龄在 20-85 岁之间（平均值 ± SD；49.9 ± 14.9）。值得注意的是，46.0%的癌症患者有癌症家族史。CC与体重指数异常（体重不足和超重）、阳性吸烟史和阳性癌症家族史之间存在直接关系：结论：体重不足或超重是CC患者的潜在风险因素。在临床上，CC 患者的总体生存率与确诊前的生活方式选择有关。应向社区和接受结肠镜筛查的患者强烈推荐均衡饮食、步行和其他形式的运动。
Body Mass Index and Other Risk Factors Effects on Colon Cancer Prognosis in Pakistan.
Introduction: Asian developing countries share the burden of colorectal cancer (CRC) with rising mortality rates. This prospective study aims to apprehend the clinical relevance of age, gender, lifestyle choices (dietary habits and addiction) and body mass index (BMI) to the occurrence and progression of colon cancer (CC).
Methods: A cohort of non-cancer (NC) and CC patients of South-Central Asian origin registered for screening colonoscopy or surgery at Shaukat Khanum Memorial Cancer Hospital and Research Centre (SKMCH and RC), Lahore, Pakistan, from 2015 to 2020 was identified. BMI (Kg/m2) was classified according to the World Health Organization criteria as underweight (<18.5 Kg/m2), normal weight (18.5-24.9 Kg/m2) and overweight (≥25 Kg/m2).
Results: Among 236 participants, 99 (41.9%) belonged to the NC group, and 137 (58.1 %) participants had CC Overall, participants included 74 women and 162 men aged 20-85 years (mean ± SD; 49.9 ± 14.9). Notably, 46.0% of cancer patients had a family history of cancer. There was a direct relationship between CC with abnormal BMI (underweight and overweight), positive smoking history and positive family history of cancer.
Conclusion: Being underweight or overweight is a potential risk factor for CC patients. The overall survival in patients with CC is clinically associated with lifestyle choices before CC diagnosis. A balanced diet, walking and other forms of exercise should be strongly recommended to the community and those undergoing screening colonoscopy.
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