人源性真皮成纤维细胞作为研究精神疾病昼夜节律的体外研究工具。

IF 3.6 3区医学 Q2 PHARMACOLOGY & PHARMACY

Pharmacopsychiatry Pub Date : 2023-05-01 DOI:10.1055/a-1147-1552

Denise Palm, Adriana Uzoni, Golo Kronenberg, Johannes Thome, Frank Faltraco

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引用次数: 2

摘要

许多精神疾病被定义为持续或反复的睡眠-觉醒障碍，以及昼夜节律的中断和时钟基因表达的改变。昼夜节律不仅存在于下丘脑视交叉上核，也存在于外周组织。在这方面，人源性真皮成纤维细胞的培养可以作为一种有前途的新工具来研究精神疾病病理生理学基础上的细胞和分子机制。本文讨论了成纤维细胞培养在精神疾病研究中的优势。更具体地说，我们提供了利用人类成纤维细胞模拟昼夜节律紊乱的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Human Derived Dermal Fibroblasts as in Vitro Research Tool to Study Circadian Rhythmicity in Psychiatric Disorders.

A number of psychiatric disorders are defined by persistent or recurrent sleep-wake disturbances alongside disruptions in circadian rhythm and altered clock gene expression. Circadian rhythms are present not only in the hypothalamic suprachiasmatic nucleus but also in peripheral tissues. In this respect, cultures of human derived dermal fibroblasts may serve as a promising new tool to investigate cellular and molecular mechanisms underlying the pathophysiology of mental illness. In this article, we discuss the advantages of fibroblast cultures to study psychiatric disease. More specifically, we provide an update on recent advances in modeling circadian rhythm disorders using human fibroblasts.

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来源期刊

Pharmacopsychiatry 医学-精神病学

CiteScore

7.10

自引率

9.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Covering advances in the fi eld of psychotropic drugs, Pharmaco psychiatry provides psychiatrists, neuroscientists and clinicians with key clinical insights and describes new avenues of research and treatment. The pharmacological and neurobiological bases of psychiatric disorders are discussed by presenting clinical and experimental research.