来自摩洛哥病例对照研究的结直肠癌相关饮食模式的聚类分析

IF 4.1 Q1 HEALTH CARE SCIENCES & SERVICES
Noura Qarmiche, Khaoula El Kinany, Nada Otmani, Karima El Rhazi, Nour El Houda Chaoui
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引用次数: 0

摘要

结直肠癌(CRC)是一个全球性的公共卫生问题。有强有力的迹象表明,营养可能是初级预防的一个重要组成部分。饮食模式是了解不同人群饮食与癌症之间关系的有力手段。目的:我们使用无监督机器学习方法对与CRC相关的摩洛哥饮食模式进行聚类。方法:以1483对结直肠癌配对病例和对照组的营养报告为基础进行研究。基线膳食摄入量是使用经过验证的适合摩洛哥环境的食物频率问卷来测量的。通过主成分分析(PCA),在6个维度上将食品分类为30个食品类群。结果:应用于pca子空间的K-means方法确定了两种模式:“谨慎模式”(几乎所有食物的适度消费,水果和蔬菜的摄入量略有增加)和“危险模式”(植物油、蛋糕、巧克力、奶酪、红肉、糖和黄油),成分和集群之间的差异很小。学生测试显示,群集与除家禽外的所有食物消费之间存在显著关系。简单逻辑回归检验显示,属于“危险模式”的人患结直肠癌的风险更高,OR为1.59,95% CI(1.37至1.38)。结论:提出的算法应用于CCR营养数据库,确定了与CRC相关的两种饮食特征:“危险模式”和“谨慎模式”。本研究的结果可能有助于推荐摩洛哥人群的结直肠癌预防饮食。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cluster analysis of dietary patterns associated with colorectal cancer derived from a Moroccan case-control study.

Introduction: Colorectal cancer (CRC) is a global public health problem. There is strong indication that nutrition could be an important component of primary prevention. Dietary patterns are a powerful technique for understanding the relationship between diet and cancer varying across populations.

Objective: We used an unsupervised machine learning approach to cluster Moroccan dietary patterns associated with CRC.

Methods: The study was conducted based on the reported nutrition of CRC matched cases and controls including 1483 pairs. Baseline dietary intake was measured using a validated food-frequency questionnaire adapted to the Moroccan context. Food items were consolidated into 30 food groups reduced on 6 dimensions by principal component analysis (PCA).

Results: K-means method, applied in the PCA-subspace, identified two patterns: 'prudent pattern' (moderate consumption of almost all foods with a slight increase in fruits and vegetables) and a 'dangerous pattern' (vegetable oil, cake, chocolate, cheese, red meat, sugar and butter) with small variation between components and clusters. The student test showed a significant relationship between clusters and all food consumption except poultry. The simple logistic regression test showed that people who belong to the 'dangerous pattern' have a higher risk to develop CRC with an OR 1.59, 95% CI (1.37 to 1.38).

Conclusion: The proposed algorithm applied to the CCR Nutrition database identified two dietary profiles associated with CRC: the 'dangerous pattern' and the 'prudent pattern'. The results of this study could contribute to recommendations for CRC preventive diet in the Moroccan population.

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来源期刊
CiteScore
6.10
自引率
4.90%
发文量
40
审稿时长
18 weeks
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