草药的表观遗传效应。

IF 5.7 2区 医学 Q1 Medicine
Yu-Yao Wu, Yan-Ming Xu, Andy T Y Lau
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引用次数: 1

摘要

表观遗传记忆是控制细胞预定义功能特征的生命所必需的。最近的证据表明,表观遗传修饰提供了可能参与各种慢性疾病发展的基因表达变化的潜在联系,并且靶向表观基因组成为治疗疾病的可行方法。传统草药以其低毒性和治疗疾病的功效逐渐进入研究者的视野。事实上,研究人员发现,草药所具有的表观遗传修饰能力具有对抗疾病进展的能力,如各种类型的癌症、糖尿病、炎症、健忆症、肝纤维化、哮喘和高血压引起的肾损伤。对草药表观遗传效应的研究将为人类疾病的分子机制提供有价值的见解,这可能会导致新的治疗方法和诊断。因此,本文综述了草药及其生物活性成分对疾病表观基因组的影响,并举例说明如何利用表观遗传可塑性作为未来发展慢性疾病靶向治疗的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Epigenetic effects of herbal medicine.

Epigenetic effects of herbal medicine.

Epigenetic memory is essential for life that governs the predefined functional features of cells. Recent evidence has indicated that the epigenetic modification provides a potential link to gene expression changes that may be involved in the development of various chronic diseases, and targeting the epigenome becomes a plausible method for treating diseases. Traditional herbal medicine has gradually entered the vision of researchers due to its low toxicity and its effectiveness in treating diseases. As a matter of fact, researchers found that the possessed epigenetic modification capacity of herbal medicine had the ability to combat the progression of the disease, such as various types of cancer, diabetes, inflammation, amnesia, liver fibrosis, asthma, and hypertension-induced renal injury. Studies on the epigenetic effects of herbal medicine will provide valuable insights into the molecular mechanisms of human diseases, which may lead to new therapeutic approaches and diagnoses. Thus, this review summarized the impact of herbal medicine and its bioactive components on disease epigenome as examples of how utilization of epigenetic plasticity could be useful as the basis for the future development of targeted therapies in chronic diseases.

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来源期刊
Clinical Epigenetics
Clinical Epigenetics Biochemistry, Genetics and Molecular Biology-Developmental Biology
CiteScore
8.90
自引率
5.30%
发文量
150
审稿时长
12 weeks
期刊介绍: Clinical Epigenetics, the official journal of the Clinical Epigenetics Society, is an open access, peer-reviewed journal that encompasses all aspects of epigenetic principles and mechanisms in relation to human disease, diagnosis and therapy. Clinical trials and research in disease model organisms are particularly welcome.
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