[3 + 2]硫代硫甙与噻唑烷-2-羧酸的环加成反应:制备新的杂环支架的通用途径。

Organic and Medicinal Chemistry Letters Pub Date : 2011-09-06 DOI:10.1186/2191-2858-1-6

Sonali Verma, Johnson George, Saurabh Singh, Pushpa Pardasani, Ramchand Pardasani

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引用次数: 4

摘要

在各种富电子和缺电子亲极试剂的存在下，硫代硫甙与噻唑烷-2-羧酸进行1,3-偶极环加成反应，可快速合成氮杂环加合物。通过理论计算研究了产物的区域选择性。分析了不同反应物、过渡态和形成的环加合物的几何和能量性质。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

[3 + 2] Cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid: a versatile route to new heterocyclic scaffolds.

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[3 + 2] Cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid: a versatile route to new heterocyclic scaffolds.

A facile synthesis of azabicycloadducts is described by 1,3-dipolar cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid in the presence of various electron rich and electron deficient dipolarophiles. Theoritical calculations have been performed to study the regioselectivity of products. The geometrical and energetic properties have been analyzed for the different reactants, transition states and cycloadducts formed.

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Organic and Medicinal Chemistry Letters

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