生酮饮食与β -羟基丁酸盐在结直肠癌中的作用。

IF 2.6 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
DNA and cell biology Pub Date : 2022-12-01 Epub Date: 2022-11-29 DOI:10.1089/dna.2022.0486
Svetlana Khoziainova, Galina Rozenberg, Maayan Levy
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引用次数: 4

摘要

结直肠癌(CRC)是美国癌症相关死亡的主要原因之一。虽然某些遗传易感性可能会增加患结直肠癌的风险,但饮食和生活方式因素也可能起重要作用。dmitrieva - posoco等人在《自然》杂志最近的一项研究中揭示了生酮饮食在结直肠癌生长和进展中的潜在保护作用。对携带crc的小鼠给予生酮饮食显示出肿瘤抑制作用。具体来说,酮体β-羟基丁酸酯(BHB)表现出抑制上皮细胞增殖和抑制肿瘤生长的能力。BHB通过调节同源结构域蛋白Hopx作用于癌细胞,已知Hopx是CRC的调节因子。此外,BHB需要一个表面受体Hcar来诱导Hopx表达并抑制肠上皮细胞的增殖。综上所述,这些结果描述了一种利用饮食干预预防和治疗结直肠癌的新治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ketogenic Diet and Beta-Hydroxybutyrate in Colorectal Cancer.

Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the United States. Although certain genetic predispositions may contribute to one's risk for developing CRC, dietary and lifestyle factors may play an important role as well. In a recent study in Nature, Dmitrieva-Posocco et al, reveal a potential protective role of the ketogenic diet in colorectal cancer growth and progression. Administration of a ketogenic diet to CRC-bearing mice demonstrated a tumor-suppressive effect. Specifically, the ketone body β-hydroxybutyrate (BHB) exhibited the ability to suppress epithelial cell proliferation and inhibit tumor growth. BHB acts on cancer cells through regulation of homeodomain-only protein Hopx, known regulator of CRC. Furthermore, BHB requires a surface receptor Hcar to induce Hopx expression and suppress proliferation of intestinal epithelial cells. Taken together, these results describe a new therapeutic approach of using dietary intervention for the prevention and treatment of colorectal cancer.

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来源期刊
DNA and cell biology
DNA and cell biology 生物-生化与分子生物学
CiteScore
6.60
自引率
0.00%
发文量
93
审稿时长
1.5 months
期刊介绍: DNA and Cell Biology delivers authoritative, peer-reviewed research on all aspects of molecular and cellular biology, with a unique focus on combining mechanistic and clinical studies to drive the field forward. DNA and Cell Biology coverage includes: Gene Structure, Function, and Regulation Gene regulation Molecular mechanisms of cell activation Mechanisms of transcriptional, translational, or epigenetic control of gene expression Molecular Medicine Molecular pathogenesis Genetic approaches to cancer and autoimmune diseases Translational studies in cell and molecular biology Cellular Organelles Autophagy Apoptosis P bodies Peroxisosomes Protein Biosynthesis and Degradation Regulation of protein synthesis Post-translational modifications Control of degradation Cell-Autonomous Inflammation and Host Cell Response to Infection Responses to cytokines and other physiological mediators Evasive pathways of pathogens.
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