鼠油醇通过调节AMPK信号通路抑制肝癌细胞的增殖、迁移和侵袭

IF 2.6 4区 医学 Q3 CHEMISTRY, MEDICINAL
Shuang Kong, Wenchang Xiao, Tengfei Ma, Yun Chen, Hongjie Shi, Jun Tu, Jiahua Zou, Meng Zhang
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引用次数: 0

摘要

背景:肝细胞癌(HCC)是世界上最严重的恶性肿瘤之一,其5年生存率很低。目前,对于晚期原发性肝癌,临床治疗多采用系统的方法,但尚无有效的靶向治疗方法。肝癌患者药物治疗后的平均生存时间仅为3-5个月。因此,寻找新的有效的治疗HCC的药物具有重要的临床意义。Carnosol (CA)是一种存在于Lamiaceae植物中的生物活性二萜化合物,已被证明具有抗氧化、抗炎和抗癌特性。目的:本研究旨在揭示鼠油醇对肝癌的作用,为肝癌的药物治疗提供新的可能性。目的:观察鼠尾草醇对肝癌细胞表型及信号通路的影响。方法:用鼠尾草醇处理两种不同的人肝癌细胞HepG2和Huh7。用CCK-8法分析细胞的活力和增殖。Transwell法检测细胞迁移和侵袭。通过rtpcra和WB检测细胞增殖、凋亡、迁移、侵袭和信号通路的分子标记。此外,我们用抑制剂进行了救援实验,以验证受影响的信号通路。结果:鼠尾草醇能显著抑制肝癌细胞活力、增殖、集落形成、迁移和侵袭。此外,鼠尾草醇还能促进HCC细胞的凋亡。机械地,肌醇激活ampk -p53通路。结论:综上所述,我们的研究表明,鼠油醇可以通过激活AMPK-p53抑制HCC细胞的增殖、迁移、侵袭并促进细胞凋亡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
WITHDRAWN: Carnosol Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells in vitro by Regulating the AMPK Signaling Pathway

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

Bentham science disclaimer: It is a condition of publication that manuscripts submitted to this journal have not been published and will not be simultaneously submitted or published elsewhere. Furthermore, any data, illustration, structure or table that has been published elsewhere must be reported, and copyright permission for reproduction must be obtained. Plagiarism is strictly forbidden, and by submitting the article for publication the authors agree that the publishers have the legal right to take appropriate action against the authors, if plagiarism or fabricated information is discovered. By submitting a manuscript, the authors agree that the copyright of their article is transferred to the publishers if and when the article is accepted for publication.

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来源期刊
Anti-cancer agents in medicinal chemistry
Anti-cancer agents in medicinal chemistry ONCOLOGY-CHEMISTRY, MEDICINAL
CiteScore
5.10
自引率
3.60%
发文量
323
审稿时长
4-8 weeks
期刊介绍: Formerly: Current Medicinal Chemistry - Anti-Cancer Agents. Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication. Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.
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