Mariana Alves , Daniel Caldeira , Joaquim J. Ferreira
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Mean age 66 years old and 59% man. Most PD patients presented mild symptoms (mean Hoehn&Yahr 2.04). Daytime BPV was significantly higher in PD patients (SD SBP 14.1 mmHg vs 12.96 mmHg and SD DBP 9.39 mmHg vs 8.29 mmHg), but 24 h and night-time BPV were non-significantly increased. PD patients present non-significant higher night-time SBP (114 mmHg vs 110 mmHg) as well as higher frequency of non-dippers or reverse dippers BP profiles (51% vs 36%).</p></div><div><h3>Conclusion</h3><p>Our exploratory study suggests that PD patients may present a higher blood pressure variability, which may translate in an increased cardiovascular risk. 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引用次数: 0
摘要
引言帕金森病(PD)患者的心血管风险尚不确定。血压变异性(BPV)与心血管和死亡率结果相关。我们旨在评估帕金森病患者和匹配的社区对照组的血压变异性,作为心血管风险的标志。方法采用横断面病例对照研究。分析中包括的所有受试者都进行了临床评估,并进行了24小时动态血压监测。使用24小时、白天和晚上的收缩压(SBP)和舒张压(DBP)的标准差(SD)来评估BPV。结果该研究包括204名参与者,每组102人。平均年龄66岁,59%为男性。大多数PD患者表现出轻微症状(平均Hoehn&;Yahr 2.04)。PD患者的日间BPV显著升高(SD SBP 14.1 mmHg vs 12.96 mmHg,SD DBP 9.39 mmHg vs 8.29 mmHg),但24小时和夜间BPV无显著升高。帕金森病患者的夜间收缩压(114 mmHg vs 110 mmHg)无显著性升高,非铲斗或反向铲斗血压谱的频率较高(51%vs 36%)。结论我们的探索性研究表明,帕金森病患者可能表现出更高的血压变异性,这可能会导致心血管风险增加。然而,还需要进一步的研究来证实这一假设和因果关系。
Blood pressure variability in Parkinson's Disease patients – Case control study
Introduction
The cardiovascular risk of Parkinson’s Disease (PD) patients is uncertain. Blood pressure variability (BPV) has been associated with cardiovascular and mortality outcomes. We aimed to evaluate blood pressure variability, as a marker of cardiovascular risk, in patients with PD and matched community controls.
Methods
Cross-sectional case-control study was performed. All subjects included in the analysis were clinically evaluated and performed a 24 h ambulatory blood pressure monitoring. BPV was assessed using standard deviations (SDs) of the systolic blood pressure (SBP) and diastolic blood pressure (DBP) for each period – 24 h, daytime, and night-time.
Results
The study included 204 participants, 102 in each group. Mean age 66 years old and 59% man. Most PD patients presented mild symptoms (mean Hoehn&Yahr 2.04). Daytime BPV was significantly higher in PD patients (SD SBP 14.1 mmHg vs 12.96 mmHg and SD DBP 9.39 mmHg vs 8.29 mmHg), but 24 h and night-time BPV were non-significantly increased. PD patients present non-significant higher night-time SBP (114 mmHg vs 110 mmHg) as well as higher frequency of non-dippers or reverse dippers BP profiles (51% vs 36%).
Conclusion
Our exploratory study suggests that PD patients may present a higher blood pressure variability, which may translate in an increased cardiovascular risk. However, further studies are needed to confirm this hypothesis and causality.