新生b细胞前淋巴细胞白血病。

IF 1.3 Q4 HEMATOLOGY
Sasmith R Menakuru, Janet Roepke, Salahuddin Siddiqui
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引用次数: 0

摘要

B细胞原淋巴细胞白血病(B- pll)是一种罕见的B细胞肿瘤,典型表现为脾肿大,白细胞计数升高,可能有也可能没有B症状。诊断通常需要骨髓活检和流式细胞术和细胞遗传学研究的抽吸。外周血中至少55%的淋巴细胞为原淋巴细胞才被定义为B-PLL。彻底的鉴别诊断应包括套细胞淋巴瘤、伴前淋巴细胞的慢性淋巴细胞白血病、毛细胞白血病和脾边缘带淋巴瘤。B-PLL的治疗方案适用于CLL,如依鲁替尼和利妥昔单抗,但针对每个人量身定制。作者报告了一例罕见的B-PLL病例,患者没有已知的CLL病史。作者在2017年和2022年世界卫生组织(WHO)分类的背景下讨论了这一实体,后者不再将B-PLL视为一个独立的实体。希望本文能对临床医师对B-PLL的诊断和治疗有所帮助。也许随着对这些罕见病例的更好的认识和更好的组织病理学特征的记录,它可能在未来的分类中再次被证明是一个独特的实体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

<i>De-Novo</i> B-Cell Prolymphocytic Leukemia.

<i>De-Novo</i> B-Cell Prolymphocytic Leukemia.

<i>De-Novo</i> B-Cell Prolymphocytic Leukemia.

De-Novo B-Cell Prolymphocytic Leukemia.

B-cell prolymphocytic leukemia (B-PLL) is a rare B-cell neoplasm that typically presents with splenomegaly, a rising white blood cell count, and may or may not have B symptoms. The diagnosis usually requires a bone marrow biopsy and aspirate with flow cytometry and cytogenetic studies. At least 55% of the lymphocytes in the peripheral blood must be prolymphocytes to be defined as B-PLL. A thorough differential diagnosis would include mantle cell lymphoma, chronic lymphocytic leukemia (CLL) with prolymphocytes, hairy cell leukemia, and splenic marginal zone lymphoma. B-PLL is managed with regimens utilized for CLL, such as ibrutinib and rituximab but is tailored for each individual. The authors report a rare case of B-PLL in a patient with no known history of CLL. The authors discuss this entity in context of the 2017 and 2022 World Health Organization (WHO) classifications, the latter of which no longer recognizes B-PLL as a distinct entity. The authors hope that this article helps practitioners with the diagnosis and treatment of B-PLL. Perhaps with better recognition, and better documentation of histopathologic features of these rare cases going forward, it may prove to be a distinct entity again in future classifications.

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来源期刊
Journal of hematology
Journal of hematology HEMATOLOGY-
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