Mónika Révész, Ferenc Oberna, András Slezák, Örs Ferenczi, István Kenessey, Zoltán Takácsi-Nagy
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引用次数: 0
摘要
我们旨在分析85例年轻患者(≤39岁,中位年龄:37岁;2000-2018年之间),与140名机构普通HNSCC患者(中位年龄:61.5岁)相比。患者的医疗记录是从机构数据库中收集的。年轻人群中吸烟和饮酒的患病率(65.8%和48.1%)高于地区人口平均水平,但低于机构一般HNSCC患者人群(86.4%和55%)。年轻患者原发肿瘤部位为口腔(56.4%)、口咽部(17.6%)、下咽(11.7%)、喉部(14.1%)。年轻组的累积5年总生存率为44.2%,但早期T组明显更好(T1-2 vs T3-4: 52.6% vs 26.7%;p = 0.0058)和N0状态(N0 vs. N+: 65.2% vs. 32.3%;P = 0.0013)。年轻、戒酒、早期和喉部肿瘤部位可能预示较好的预后。年轻患者的年龄分布和传统危险因素的高发,以及口腔肿瘤定位的优势,提示肿瘤的早发性发展可能源于内在保护机制的过早失效。
The characteristics of head and neck squamous cell cancer in young adults: A retrospective single-center study.
We aimed to characterize clinical and prognostical factors of primary head and neck squamous cell carcinoma (HNSCC) in 85 young patients (≤39 years, median age: 37 years; between 2000-2018) in comparison with 140 institutional general HNSCC patients (median age: 61.5 years). The patient's medical records were collected from the institutional database. The prevalence of smoking and alcohol consumption (65.8% and 48.1%) in the young group exceeded the regional population average but was below the institutional (86.4% and 55%) general HNSCC patient population. Primary tumor sites in the group of young patients were as follows: oral cavity (56.4%), oropharynx (17.6%), hypopharynx (11.7%), and larynx (14.1%). Cumulative five-year overall survival was 44.2% in the young group, but significantly better with early T (T1-2 vs. T3-4: 52.6% vs. 26.7%; p = 0.0058) and N0 status (N0 vs. N+: 65.2% vs. 32.3%; p = 0.0013). Young age, abstinence, earlier stage and laryngeal tumor site might predict a better prognosis. The age distribution and the high prevalence of traditional risk factors among the young patients as well as the predominance of oral cavity tumor localization suggest that the early onset of tumor development could be originated from the premature failure of the intrinsic protective mechanisms.
期刊介绍:
Pathology & Oncology Research (POR) is an interdisciplinary Journal at the interface of pathology and oncology including the preclinical and translational research, diagnostics and therapy. Furthermore, POR is an international forum for the rapid communication of reviews, original research, critical and topical reports with excellence and novelty. Published quarterly, POR is dedicated to keeping scientists informed of developments on the selected biomedical fields bridging the gap between basic research and clinical medicine. It is a special aim for POR to promote pathological and oncological publishing activity of colleagues in the Central and East European region. The journal will be of interest to pathologists, and a broad range of experimental and clinical oncologists, and related experts. POR is supported by an acknowledged international advisory board and the Arányi Fundation for modern pathology.