预防性单次静脉注射右酮洛芬能减轻正颌手术后的疼痛和肿胀吗?一项前瞻性、随机、双盲临床试验。

IF 2.2 3区 医学
Y-N Kaba, A-E Demirbas, N Kütük, D-G Canpolat, A Alkan
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引用次数: 2

摘要

背景:本研究的目的是评价单剂量静脉注射右酮洛芬预防镇痛对双颌手术术后疼痛和消肿的影响。材料和方法:作者设计了一项前瞻性、随机、双盲队列研究。III类错牙合患者随机分为两组。治疗组在切口前30分钟静脉给予右酮洛芬曲美他醇50 mg,安慰剂组在切口前30分钟静脉给予无菌生理盐水。主要预测变量为治疗组。主要结局是疼痛、肿胀和24小时阿片类药物摄入。术后疼痛给予曲马多患者自控镇痛。其他变量为人口统计和手术相关参数。采用视觉模拟评分法评价术后疼痛。3dMD面部系统(3dMD, USA)用于测量术后肿胀。数据分析采用两个独立样本t检验和Mann Whitney U检验。结果:研究样本由30例患者组成,平均年龄20岁,63岁,女性21例。与安慰剂组相比,预先给药右酮洛芬组术后曲马多用量减少25.9%,VAS评分降低有统计学意义(p0,05)。结论:预防性静脉注射右酮洛芬可在术后24小时内提供足够的镇痛效果,减少正颌手术中阿片类药物的消耗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Does preventive single dose of intravenous dexketoprofen reduce pain and swelling after orthognathic surgery? A prospective, randomized, double blind clinical trial.

Does preventive single dose of intravenous dexketoprofen reduce pain and swelling after orthognathic surgery? A prospective, randomized, double blind clinical trial.

Does preventive single dose of intravenous dexketoprofen reduce pain and swelling after orthognathic surgery? A prospective, randomized, double blind clinical trial.

Does preventive single dose of intravenous dexketoprofen reduce pain and swelling after orthognathic surgery? A prospective, randomized, double blind clinical trial.

Background: The purpose of this study was to evaluate the effect of a single-dose intravenous dexketoprofen administration for preventive analgesia on postoperative pain and reducing swelling in double jaw surgery.

Material and methods: The authors designed a prospective, randomized, and double-blind cohort study. Patients who have Class III malocclusion were randomly divided in two groups. 50 mg intravenous dexketoprofen trometamol were administrated 30 minutes before incision in treatment group, while intravenous sterile saline was administrated 30 minutes before incision in placebo group. The primary predictor variable was treatment group. Primary outcomes were pain, swelling and 24-hour opioid intake. Patient- controlled analgesia with tramadol was given for management of postoperative pain. Other variables were demographic and operation related parameters. Visual analogue scale was used to evaluate postoperative pain. 3dMD Face System (3dMD, USA) was used to measure postoperative swelling. Data were analysed using two independent samples t test and Mann Whitney U test.

Results: The study sample was composed of 30 patients with a mean age of 20,63 years and 21 were female. Preemptive dexketoprofen administration decreased postoperative tramadol consumption by 25.9% compared to placebo group, and there was a statistically significant decrease in VAS scores (p<0,05). There was no statistically significant difference between the groups in terms of swelling (p>0,05).

Conclusions: Preventive administration of intravenous dexketoprofen provides adequate analgesic effect in the postoperative 24-hour period and reduces opioid consumption in orthognathic surgery.

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来源期刊
CiteScore
4.50
自引率
0.00%
发文量
52
期刊介绍: 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology
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