John D Olson , Janet A Tooze , Daniel J Bourland , J Mark Cline , Eduardo B Faria , Eric P Cohen
{"title":"肾皮质纤维化的CT测量","authors":"John D Olson , Janet A Tooze , Daniel J Bourland , J Mark Cline , Eduardo B Faria , Eric P Cohen","doi":"10.1016/j.redii.2023.100024","DOIUrl":null,"url":null,"abstract":"<div><h3>Rationale and objectives</h3><p>The accurate, non-invasive, and rapid measurement of renal cortical fibrosis is needed for well-defined benchmarks of permanent injury and for use of anti-fibrotic agents. It is also needed for non-invasive and rapid assessment of the chronicity of human renal diseases.</p></div><div><h3>Materials and methods</h3><p>We have used a non-human primate model of radiation nephropathy to develop a novel method of size-corrected CT imaging to quantify renal cortical fibrosis.</p></div><div><h3>Results</h3><p>Our method has an area under the receiver operating curve of 0.96, which is superior to any other non-invasive method of measuring renal fibrosis.</p></div><div><h3>Conclusion</h3><p>Our method is suitable for immediate translation to human clinical renal diseases.</p></div>","PeriodicalId":74676,"journal":{"name":"Research in diagnostic and interventional imaging","volume":"5 ","pages":"Article 100024"},"PeriodicalIF":0.0000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124964/pdf/","citationCount":"0","resultStr":"{\"title\":\"Measurement of renal cortical fibrosis by CT scan\",\"authors\":\"John D Olson , Janet A Tooze , Daniel J Bourland , J Mark Cline , Eduardo B Faria , Eric P Cohen\",\"doi\":\"10.1016/j.redii.2023.100024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Rationale and objectives</h3><p>The accurate, non-invasive, and rapid measurement of renal cortical fibrosis is needed for well-defined benchmarks of permanent injury and for use of anti-fibrotic agents. It is also needed for non-invasive and rapid assessment of the chronicity of human renal diseases.</p></div><div><h3>Materials and methods</h3><p>We have used a non-human primate model of radiation nephropathy to develop a novel method of size-corrected CT imaging to quantify renal cortical fibrosis.</p></div><div><h3>Results</h3><p>Our method has an area under the receiver operating curve of 0.96, which is superior to any other non-invasive method of measuring renal fibrosis.</p></div><div><h3>Conclusion</h3><p>Our method is suitable for immediate translation to human clinical renal diseases.</p></div>\",\"PeriodicalId\":74676,\"journal\":{\"name\":\"Research in diagnostic and interventional imaging\",\"volume\":\"5 \",\"pages\":\"Article 100024\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10124964/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Research in diagnostic and interventional imaging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2772652523000030\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research in diagnostic and interventional imaging","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772652523000030","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The accurate, non-invasive, and rapid measurement of renal cortical fibrosis is needed for well-defined benchmarks of permanent injury and for use of anti-fibrotic agents. It is also needed for non-invasive and rapid assessment of the chronicity of human renal diseases.
Materials and methods
We have used a non-human primate model of radiation nephropathy to develop a novel method of size-corrected CT imaging to quantify renal cortical fibrosis.
Results
Our method has an area under the receiver operating curve of 0.96, which is superior to any other non-invasive method of measuring renal fibrosis.
Conclusion
Our method is suitable for immediate translation to human clinical renal diseases.
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