Second generation platelet concentrates in periodontal surgery: A narrative review and clinical perspectives.

Objective: The aim of this article is to analyze the latest scientific literature and focus on the development of second-generation platelet concentrates: platelet-rich fibrin (PRF) and concentrated growth factor (CGF), their fabrication procedure and capability in periodontal surgery.

Material and methods: Scientific articles published in English were selected from PubMed and Cochrane Library databases according to selected keywords. Duplicate and off-topic articles were excluded from further analysis.

Conclusion: PRF and CGF can be considered beneficial biomaterials because they are reported to have favorable biological effects, are low in cost and easier to prepare compared to first generation platelet concentrates and do not cause side effects. Although PRF and CGF demonstrate promising results in the regeneration of intrabony defects, further research is needed. Same as with furcation defect therapy - more evidence of use of PRF or CGF is necessary. In gingival recession treatment PRF or CGF is not yet suggested as first option for treatment as connective tissue graft is still preferable.