{"title":"甘草香豆素的药理活性及药代动力学研究。","authors":"Yumei Tang, Shuiping Ou, Linhu Ye, Sen Wang","doi":"10.1007/s43450-022-00342-x","DOIUrl":null,"url":null,"abstract":"<p><p>Glycycoumarin is a representative coumarin compound with significant pharmacological activities isolated from <i>Glycyrrhiza uralensis</i> Fisch., Fabaceae. Studies have shown that glycycoumarin has many biological activities, such as anti-tumor, liver protection, antispasmodic, antibacterial, and antivirus. However, the poor solubility of glycycoumarin in water and the accompanying reactions of the phase I (hydroxylation) and II (glucuronidation) metabolism limit its druggability, which manifests as low absorption in the body after oral administration and low free drug concentration, ultimately leading to low bioavailability. Therefore, a comprehensive review of the pharmacological effects and pharmacokinetics of glycycoumarin is presented to provide a reference for further research and application as a therapeutic agent.</p><p><strong>Graphical abstract: </strong></p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43450-022-00342-x.</p>","PeriodicalId":21196,"journal":{"name":"Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757630/pdf/","citationCount":"0","resultStr":"{\"title\":\"Pharmacological Activities and Pharmacokinetics of Glycycoumarin.\",\"authors\":\"Yumei Tang, Shuiping Ou, Linhu Ye, Sen Wang\",\"doi\":\"10.1007/s43450-022-00342-x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Glycycoumarin is a representative coumarin compound with significant pharmacological activities isolated from <i>Glycyrrhiza uralensis</i> Fisch., Fabaceae. Studies have shown that glycycoumarin has many biological activities, such as anti-tumor, liver protection, antispasmodic, antibacterial, and antivirus. However, the poor solubility of glycycoumarin in water and the accompanying reactions of the phase I (hydroxylation) and II (glucuronidation) metabolism limit its druggability, which manifests as low absorption in the body after oral administration and low free drug concentration, ultimately leading to low bioavailability. Therefore, a comprehensive review of the pharmacological effects and pharmacokinetics of glycycoumarin is presented to provide a reference for further research and application as a therapeutic agent.</p><p><strong>Graphical abstract: </strong></p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s43450-022-00342-x.</p>\",\"PeriodicalId\":21196,\"journal\":{\"name\":\"Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757630/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s43450-022-00342-x\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s43450-022-00342-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Pharmacological Activities and Pharmacokinetics of Glycycoumarin.
Glycycoumarin is a representative coumarin compound with significant pharmacological activities isolated from Glycyrrhiza uralensis Fisch., Fabaceae. Studies have shown that glycycoumarin has many biological activities, such as anti-tumor, liver protection, antispasmodic, antibacterial, and antivirus. However, the poor solubility of glycycoumarin in water and the accompanying reactions of the phase I (hydroxylation) and II (glucuronidation) metabolism limit its druggability, which manifests as low absorption in the body after oral administration and low free drug concentration, ultimately leading to low bioavailability. Therefore, a comprehensive review of the pharmacological effects and pharmacokinetics of glycycoumarin is presented to provide a reference for further research and application as a therapeutic agent.
Graphical abstract:
Supplementary information: The online version contains supplementary material available at 10.1007/s43450-022-00342-x.
期刊介绍：
The Brazilian Journal of Pharmacognosy is a scientific journal edited and published by the Brazilian Society of Pharmacognosy, an association that brings together researchers, students and professionals who study and investigate the physical, chemical and biological drugs, especially those of vegetable origin, substances isolated and such as the potential source of drugs of natural origin. It is available in printed form for its members and subscribers and openly on the Internet in all your numbers and content. The articles published are original research contributions. To evaluate the work use is made of international standards and is held by the ad hoc advisers, which reflects the quality and credibility of the journal. The BJP is published since 1986.
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