血清素在慢性疼痛和受伤相关焦虑中的多重调节作用。

IF 2.8 4区 医学 Q2 NEUROSCIENCES
Frontiers in Synaptic Neuroscience Pub Date : 2023-04-18 eCollection Date: 2023-01-01 DOI:10.3389/fnsyn.2023.1122381
Shun Hao, Wantong Shi, Weiqi Liu, Qi-Yu Chen, Min Zhuo
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引用次数: 0

摘要

慢性疼痛是指在慢性疾病期间或疾病或受伤恢复后经常持续存在的长期疼痛。它通常会引起严重的副作用,如失眠、焦虑或抑郁,对患者的整体生活质量造成负面影响。中枢神经系统(CNS)中的羟色胺(5-HT)被认为是一种重要的神经递质和神经调节剂,可调节各种生理功能,如痛觉、认知和情绪,尤其是焦虑和抑郁。5-羟色胺受体的广泛性和多样性是其在中枢神经系统功能复杂性的基础。最近的研究发现,慢性疼痛和焦虑都与前扣带回皮层(ACC)、岛叶回皮层(IC)和脊髓的突触可塑性有关。5-HT 对 ACC 和脊髓中的突触传递和可塑性有多种调节作用,包括激活、抑制和双相作用。在本综述中,我们将讨论 5-HT 系统在慢性疼痛和受伤相关焦虑中的多种作用及其背后的突触机制。未来,特定的 5-HT 受体很可能成为有效治疗慢性疼痛和受伤相关焦虑的新靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Multiple modulatory roles of serotonin in chronic pain and injury-related anxiety.

Multiple modulatory roles of serotonin in chronic pain and injury-related anxiety.

Multiple modulatory roles of serotonin in chronic pain and injury-related anxiety.

Chronic pain is long-lasting pain that often persists during chronic diseases or after recovery from disease or injury. It often causes serious side effects, such as insomnia, anxiety, or depression which negatively impacts the patient's overall quality of life. Serotonin (5-HT) in the central nervous system (CNS) has been recognized as an important neurotransmitter and neuromodulator which regulates various physiological functions, such as pain sensation, cognition, and emotions-especially anxiety and depression. Its widespread and diverse receptors underlie the functional complexity of 5-HT in the CNS. Recent studies found that both chronic pain and anxiety are associated with synaptic plasticity in the anterior cingulate cortex (ACC), the insular cortex (IC), and the spinal cord. 5-HT exerts multiple modulations of synaptic transmission and plasticity in the ACC and the spinal cord, including activation, inhibition, and biphasic actions. In this review, we will discuss the multiple actions of the 5-HT system in both chronic pain and injury-related anxiety, and the synaptic mechanisms behind them. It is likely that the specific 5-HT receptors would be new promising therapeutic targets for the effective treatment of chronic pain and injury-related anxiety in the future.

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来源期刊
CiteScore
7.10
自引率
2.70%
发文量
74
审稿时长
14 weeks
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