Leena V Hublikar, Sharanabasava V Ganachari, Veerabhadragouda B Patil, Sahana Nandi, Aishwarya Honnad
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Anticancer potential of biologically synthesized silver nanoparticles using Lantana camara leaf extract.
A Lantana camara leaf (LC) extract was used as a mild reducing agent to produce silver metal nanoparticles (LC-AgNPs) efficiently. The size, shape, and morphology of synthesized silver nanoparticles were verified. LC-AgNPs were found in LC extract by XRD. The optimal concentrations of silver nitrate and LC extract necessary for the production of stable silver nanoparticles were determined. The LC-AgNPs were found spherical in form and monodispersed. Under optimal conditions, the round LC-AgNPs of 50-90 nm were utilized to cure lung cancer (A549 cell line) and breast cancer (MCF7) cell lines. Finally, the produced LC-AgNPs enhanced anti-cancer efficacy against A549 cells, with an IC50 = 49.52 g/mL. Similarly, the effect of LC-AgNPs on MCF7 cell line was assessed using an MTT test and inhibitory concentration (IC50) was determined found that 46.67 g/mL.
期刊介绍：
Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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