介孔羟基磷灰石和介孔生物活性玻璃壳聚糖支架。

IF 4.4 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Ana Sofia Pádua, Lígia Figueiredo, Jorge Carvalho Silva, João Paulo Borges
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引用次数: 2

摘要

骨再生是组织再生中最著名的领域之一。主要的焦点是聚合物/陶瓷复合支架。本研究以壳聚糖(CH)为基础,采用冻干法制备了不同浓度的介孔生物活性玻璃(MBG)、介孔羟基磷灰石(MHAp)和介孔生物活性玻璃(MBG)和羟基磷灰石(MC)等不同分子量和分子量的复合材料。目的是确定关于最佳形态和性能的最佳组合。试验结果表明,该支架具有高度多孔性,具有相互连接的孔隙。压缩模量随陶瓷浓度的增加而增加。75%MBG(835±160 kPa)和50%MC(1070±205 kPa)试样的力学性能提高幅度最大。随着MBG和MC浓度的增加,溶胀量分别增加到700%和900%,随着MHAp浓度的增加,溶胀量减少到400%。所有支架在12.5 mg/mL时均无细胞毒性。与CHH相比,CHL支架提高了细胞的粘附和增殖能力,而MC支架样品的效果优于仅用MBG或MHAp制备的支架样品。壳聚糖与MBG和MHAp的复合支架由于其在骨组织工程中的优异性能而被证明是最佳的组合。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass.

Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass.

Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass.

Chitosan scaffolds with mesoporous hydroxyapatite and mesoporous bioactive glass.

Bone regeneration is one of the most well-known fields in tissue regeneration. The major focus concerns polymeric/ceramic composite scaffolds. In this work, several composite scaffolds based on chitosan (CH), with low and high molecular weights, and different concentrations of ceramics like mesoporous bioactive glass (MBG), mesoporous hydroxyapatite (MHAp) and both MBG and MHAp (MC) were produced by lyophilization. The purpose is to identify the best combination regarding optimal morphology and properties. The tests of the scaffolds present a highly porous structure with interconnected pores. The compression modulus increases with ceramic concentration in the scaffolds. Furthermore, the 75%MBG (835 ± 160 kPa) and 50%MC (1070 ± 205 kPa) samples are the ones that mostly enhance increases in mechanical properties. The swelling capacity increases with MBG and MC, respectively, to 700% and 900% and decreases to 400% when MHAp concentration increases. All scaffolds are non-cytotoxic at 12.5 mg/mL. The CHL scaffolds improve cell adhesion and proliferation compared to CHH, and the MC scaffold samples, show better results than those produced with just MBG or MHAp. The composite scaffolds of chitosan with MBG and MHAp, have revealed to be the best combination due to their enhanced performance in bone tissue engineering.

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来源期刊
Progress in Biomaterials
Progress in Biomaterials MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
9.60
自引率
4.10%
发文量
35
期刊介绍: Progress in Biomaterials is a multidisciplinary, English-language publication of original contributions and reviews concerning studies of the preparation, performance and evaluation of biomaterials; the chemical, physical, biological and mechanical behavior of materials both in vitro and in vivo in areas such as tissue engineering and regenerative medicine, drug delivery and implants where biomaterials play a significant role. Including all areas of: design; preparation; performance and evaluation of nano- and biomaterials in tissue engineering; drug delivery systems; regenerative medicine; implantable medical devices; interaction of cells/stem cells on biomaterials and related applications.
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