18F-FDG PET评估高动脉炎的诊断作用和可行性:定量18F-FDG摄取的诊断效果。

Daisuke Tezuka, Yasuhiro Maejima, Tetsuo Sasano, Mitsuaki Isobe
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引用次数: 0

摘要

高须动脉炎(takasu arteritis, TAK)是由炎症引起的大血管炎。临床检查往往难以识别,18f -氟脱氧葡萄糖正电子发射断层扫描(18F-FDG PET)通过检测炎症病变的位置和分级,在诊断TAK中发挥着不可或缺的作用。18F-FDG PET的临床效用已通过临床证据确立,18F-FDG PET于2018年4月被列入日本国民健康保险清单。在TAK中,18F-FDG摄取表现出典型的结果,并且很容易区分,除了生理摄取。特别是18F-FDG PET的临床意义在于既可以显示动脉狭窄,也可以显示动脉不狭窄,这意味着可以在动脉发生不可逆狭窄之前进行治疗干预。此外,18F-FDG PET具有卓越的诊断准确性,因为它允许使用最大标准化摄取值进行定量分析。该分析用于评估TAK的疾病活动性,并可用于在随访期间重复缓解的情况下进行治疗干预。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diagnostic Role and Feasibility of 18F-FDG PET for Assessing Takayasu Arteritis: Diagnostic Efficacy of Quantifying 18F-FDG Uptake.

Takayasu arteritis (TAK) is classified as large-vessel vasculitis caused by inflammation. It is often difficult to identify on clinical examination, and 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) plays an indispensable role in diagnosing TAK by detecting the location and grade of the inflammatory lesions. The clinical utility of 18F-FDG PET has been established by clinical evidence, and 18F-FDG PET was added to the Japanese national health insurance listing in April 2018. In TAK, 18F-FDG uptake shows typical findings and is easily distinguished, except from physiological uptake. Particularly, the clinical significance of 18F-FDG PET is that can present not only with stenosis but also without stenosis in the arteries, which means that therapeutic intervention is possible before irreversible stenosis develops in the arteries. Additionally, 18F-FDG PET has superior diagnostic accuracy because it allows quantitative analysis using the maximum standardized uptake value. The analysis is used for the assessment of disease activity of TAK and can be utilized for therapeutic intervention in case of repeating remission during the follow-up term.

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