最小残留疾病对B前体急性淋巴细胞白血病晚期复发检测的重要性。

IF 0.3 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Hippokratia Pub Date : 2022-01-01

M Virijevic, N Kraguljac-Kurtovic, N Pantic, V Knezevic, M Mitrovic

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引用次数: 0

摘要

背景：B前体急性淋巴细胞白血病（B-ALL）患者的最小残留病（MRD）水平是复发和生存的最强独立预测因素。MRD的评估在B-ALL的治疗中起着至关重要的作用。病例报告：我们使用多参数流式细胞术（MFC）对一名具有MRD标准风险的30岁B-ALL女性进行了长期监测。经过五年的监测，该疾病的分子复发得到了证实。结论：该病例表明，在没有其他较新的复杂诊断方法的情况下，即使仅通过MFC对MRD进行更广泛的监测，对于检测标准风险的B-ALL患者的早期复发也是至关重要的。希波克拉蒂亚2022，26（1）：38-40。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The importance of minimal residual disease for detection of late relapse in Bprecursor acute lymphoblastic leukemia.

Background: The minimal residual disease (MRD) level in patients with B-precursor acute lymphoblastic leukemia (B-ALL) is the strongest independent predictor of relapse and survival. Assessment of MRD plays a crucial role in the treatment of B-ALL.

Case report: We performed long-term monitoring of a 30-year-old woman with B-ALL of standard risk for MRD using multiparametric flow cytometry (MFC). After five years of monitoring, molecular relapse of the disease was confirmed.

Conclusion: This case illustrates that more extended monitoring for MRD, even by only MFC when other newer sophisticated diagnostics are not available, is essential in detecting early relapse in patients with B-ALL of standard risk. HIPPOKRATIA 2022, 26 (1):38-40.

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来源期刊

Hippokratia MEDICINE, GENERAL & INTERNAL-

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Hippokratia journal is a quarterly issued, open access, peer reviewed, general medical journal, published in Thessaloniki, Greece. It is a forum for all medical specialties. The journal is published continuously since 1997, its official language is English and all submitted manuscripts undergo peer review by two independent reviewers, assigned by the Editor (double blinded review process). Hippokratia journal is managed by its Editorial Board and has an International Advisory Committee and over 500 expert Reviewers covering all medical specialties and additionally Technical Reviewers, Statisticians, Image processing Experts and a journal Secretary. The Society “Friends of Hippokratia Journal” has the financial management of both the printed and electronic edition of the journal.