患者对多种癌症早期检测(MCED)筛查试验的偏好。

IF 3.4 3区 医学 Q1 HEALTH CARE SCIENCES & SERVICES
Heather Gelhorn, Melissa M Ross, Anuraag R Kansal, Eric T Fung, Michael V Seiden, Nicolas Krucien, Karen C Chung
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引用次数: 4

摘要

背景:新兴的基于血液的多种癌症早期检测(MCED)测试可以检测各种不同阶段的癌症类型,具有一定的敏感性、特异性和预测癌症信号起源的能力。然而,对于一般美国人对MCED测试的偏好知之甚少。目的:使用离散选择实验(DCE)量化50-80岁美国成年人对MCED测试的偏好。方法:为了量化对基于血液的MCED测试属性的偏好,通过在线小组和社交媒体在50-80岁的美国人群中进行了一项在线DCE,其中包含五个属性(真阳性、假阴性、假阳性、未知癌症类型的可能性、检测到的癌症类型数量)。采用潜类多项式逻辑模型对数据进行分析,得出相对属性重要性。结果:1700名参与者中,女性占54%,平均年龄63.3岁。潜在类别模型确定了三个类别对MCED测试有不同的偏好。基于相对属性重要性的属性重要性的等级顺序因潜在类别而异,但在所有潜在类别中,参与者倾向于更高的准确性(更少的假阴性和假阳性,更多的真阳性)和检测到更多癌症类型的筛查,并且癌症类型未知的可能性更低。总体而言,除了目前推荐的癌症筛查外,72%的参与者更愿意接受MCED检测。结论:虽然癌症筛查偏好存在显著的异质性,但大多数参与者更倾向于MCED筛查,这些测试的准确性很重要。虽然大多数参与者倾向于增加MCED测试来补充当前的癌症筛查,但潜在类别分析确定了一小部分(16%)特定的个体,他们对属性的价值不同,特别关注假阴性和假阳性测试结果,他们选择加入的可能性显着降低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Patient Preferences for Multi-Cancer Early Detection (MCED) Screening Tests.

Background: Emerging blood-based multi-cancer early detection (MCED) tests can detect a variety of cancer types across stages with a range of sensitivity, specificity, and ability to predict the origin of the cancer signal. However, little is known about the general US population's preferences for MCED tests.

Objective: To quantify preferences for MCED tests among US adults aged 50-80 years using a discrete choice experiment (DCE).

Methods: To quantify preferences for attributes of blood-based MCED tests, an online DCE was conducted with five attributes (true positives, false negatives, false positives, likelihood of the cancer type unknown, number of cancer types detected), among the US population aged 50-80 years recruited via online panels and social media. Data were analyzed using latent class multinomial logit models and relative attribute importance was obtained.

Results: Participants (N = 1700) were 54% female, mean age 63.3 years. Latent class modeling identified three classes with distinct preferences for MCED tests. The rank order of attribute importance based on relative attribute importance varied by latent class, but across all latent classes, participants preferred higher accuracy (fewer false negatives and false positives, more true positives) and screenings that detected more cancer types and had a lower likelihood of cancer type unknown. Overall, 72% of participants preferred to receive an MCED test in addition to currently recommended cancer screenings.

Conclusions: While there is significant heterogeneity in cancer screening preferences, the majority of participants preferred MCED screening and the accuracy of these tests is important. While the majority of participants preferred adding an MCED test to complement current cancer screenings, the latent class analyses identified a small (16%) and specific subset of individuals who value attributes differently, with particular concern regarding false-negative and false-positive test results, who are significantly less likely to opt-in.

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来源期刊
Patient-Patient Centered Outcomes Research
Patient-Patient Centered Outcomes Research HEALTH CARE SCIENCES & SERVICES-
CiteScore
6.60
自引率
8.30%
发文量
44
审稿时长
>12 weeks
期刊介绍: The Patient provides a venue for scientifically rigorous, timely, and relevant research to promote the development, evaluation and implementation of therapies, technologies, and innovations that will enhance the patient experience. It is an international forum for research that advances and/or applies qualitative or quantitative methods to promote the generation, synthesis, or interpretation of evidence. The journal has specific interest in receiving original research, reviews and commentaries related to qualitative and mixed methods research, stated-preference methods, patient reported outcomes, and shared decision making. Advances in regulatory science, patient-focused drug development, patient-centered benefit-risk and health technology assessment will also be considered. Additional digital features (including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations) can be published with articles; these are designed to increase the visibility, readership and educational value of the journal’s content. In addition, articles published in The Patient may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand important medical advances. All manuscripts are subject to peer review by international experts.
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