原发性高血压患者对氨氯地平的心血管自主神经反应。

Youssouf Radjab, Souad Aboudrar, Fatima Zahra Milouk, Hanan Rkain, Mustapha El Bakkali, Taoufiq Dakka, Leslie Coghlan, Halima Benjelloun
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引用次数: 5

摘要

交感神经亢进可能与原发性高血压有关。本研究的目的是评估接受氨氯地平作为降压药的患者的交感神经和迷走神经活动反应。患者和方法。本前瞻性研究纳入了一组原发性高血压患者(N = 32,平均年龄54.6±7.6岁)。该组患者在每日口服氨氯地平3个月前后进行心血管自主神经测试,包括深呼吸、握力和精神压力测试。统计分析采用学生t检验。结果。口服氨氯地平前后3个月的心血管自主反射反应如下:精神应激试验刺激法产生中枢α肾上腺素能反应23.9±8.7%比11.2±2.0% (P < 0.05),中枢β交感反应16.7±9.2%比10.4±1.3% (P < 0.05),握力试验血压升高20.5±7.3%比10.7±2.4% (P < 0.05),深呼吸试验迷走神经反应21.2±6.5%比30.8±2.9% (P < 0.05)。结论。结果证明氨氯地平可能具有抗交感神经作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cardiovascular autonomic response to amlodipine in primary hypertension.

Cardiovascular autonomic response to amlodipine in primary hypertension.

Sympathetic hyperactivity may be involved in primary hypertension. The purpose of this study was to evaluate both sympathetic and vagal activity responses in patients receiving amlodipine as antihypertensive agent. Patients and Methods. This prospective study included a group of primary hypertensive patients (N = 32, mean age 54.6 ± 7.6 years). The cardiovascular autonomic tests performed in this group, before and after 3 months of daily oral administration of amlodipine, included deep breathing, hand-grip, and mental stress tests. Statistical analysis was done using the Student's t-test. Results. Cardiovascular autonomic reflexes responses before and after 3 months of amlodipine oral administration were as follows: the mental stress test stimulation method produced a central alpha adrenergic response of 23.9 ± 8.7% versus 11.2 ± 2.0% (P < 0.05), a central beta sympathetic response of 16.7 ± 9.2% versus 10.4 ± 1.3% (P < 0.05), a blood pressure increase in response to hand grip test of 20.5 ± 7.3% versus 10.7 ± 2.4% (P < 0.05), vagal response to deep breathing test was 21.2 ± 6.5% versus 30.8 ± 2.9%, (P < 0.05). Conclusion. The results attest that amlodipine may have an anti-sympathetic effect.

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