早期姑息治疗对提高晚期癌症患者生活质量的影响:随机对照试验的元分析。

IF 1.1 Q4 HEALTH CARE SCIENCES & SERVICES
Indian Journal of Palliative Care Pub Date : 2023-01-01 Epub Date: 2022-09-07 DOI:10.25259/IJPC_153_2022
Made Satya Nugraha Gautama, Adelina Damayanti, Anindita Farda Khusnia
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引用次数: 2

摘要

姑息治疗通常在危及生命的情况下开始较晚,特别是在晚期癌症患者中。然而,随着早期姑息治疗(EPC)范式的出现,他们的生活质量(QoL)可能会更好。尽管之前的几项荟萃分析支持EPC在提高生活质量方面的有效性,但仍需要与EPC干预措施的优化相关的基本问题。对随机对照试验(RCT)进行了系统回顾和荟萃分析,以确定EPC对晚期癌症患者生活质量的有效性。PubMed、ProQuest、MEDLINE通过EBSCOhost和Cochrane图书馆以及clinicaltrials.gov(注册网站)搜索2022年5月之前发布的随机对照试验。数据综合使用Review Manager 5.4生成效应大小的汇总估计值。共有12项经验试验符合资格标准,并被纳入本研究。结果显示,EPC干预有显著效果(标准平均差=0.16,95%置信区间:0.040.28,Z=2.68,P<0.05),但次要结果包括情绪(平均差=0.90,95%CI:-2.32,0.51,P>0.05)和症状控制(MD=-1.49,95%CI:-3.81,0.81,P>0.05)没有显著效果。EPC能有效改善晚期癌症患者的生活质量。然而,其他结果仍需审查,因为对生活质量的审查不足以概括EPC干预措施的有效性和优化的基准。另一个值得注意的方面是考虑开始和结束EPC干预的最有效和最高效的持续时间。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Impact of Early Palliative Care to Improve Quality of Life of Advanced Cancer Patients: A Meta-Analysis of Randomised Controlled Trials.

Impact of Early Palliative Care to Improve Quality of Life of Advanced Cancer Patients: A Meta-Analysis of Randomised Controlled Trials.

Impact of Early Palliative Care to Improve Quality of Life of Advanced Cancer Patients: A Meta-Analysis of Randomised Controlled Trials.

Impact of Early Palliative Care to Improve Quality of Life of Advanced Cancer Patients: A Meta-Analysis of Randomised Controlled Trials.

Palliative care is often started late in patients with life-threatening conditions, particularly in patients with advanced cancer. However, with the emergence of the early palliative care (EPC) paradigm, their quality of life (QoL) may be better. Although several previous meta-analyses support the effectiveness of EPC in increasing QoL, essential issues related to the optimisation of EPC interventions are still needed. A systematic review and meta-analysis of randomised controlled trials (RCTs) were conducted to determine the effectiveness of EPC on the QoL of patients with advanced cancer. PubMed, ProQuest, MEDLINE through EBSCOhost and Cochrane Library and clinicaltrials.gov (register website) were searched for RCTs published before May 2022. Data synthesis used the Review Manager 5.4 to generate pooled estimates of effect size. A total of 12 empirical trials met the eligibility criteria and were included in this study. The results showed that EPC intervention had a significant effect (standard mean difference = 0.16, 95% confidence interval: 0.04, 0.28, Z = 2.68, P < 0.05). However, the secondary outcomes showed including mood (mean difference = -0.90, 95% CI: -2.32, 0.51, P > 0.05) and symptom controls (MD = -1.49, 95% CI: -3.81, 0.81, P > 0.05) had no significant effect. EPC is effective in improving the QoL of patients with advanced cancer. However, other outcomes still need to be reviewed, because the review of QoL is not enough to generalise the benchmarks for the effectiveness and optimisation of EPC interventions. Another notable aspect is to consider the most effective and efficient duration for starting and ending EPC interventions.

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来源期刊
Indian Journal of Palliative Care
Indian Journal of Palliative Care HEALTH CARE SCIENCES & SERVICES-
CiteScore
2.30
自引率
0.00%
发文量
57
期刊介绍: Welcome to the website of the Indian Journal of Palliative Care. You have free full text access to recent issues of the journal. The links connect you to •guidelines and systematic reviews in palliative care and oncology •a directory of palliative care programmes in India and IAPC membership •Palliative Care Formulary, book reviews and other educational material •guidance on statistical tests and medical writing.
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