Alf Inge Larsen, Charlotte Sæland, Johnny Vegsundvåg, Mette Storebø Skadberg, Jorunn Nilsen, Noreen Butt, Anastasia Ushakova, Torstein Valborgland, Peter Scott Munk, Kjetil Isaksen
{"title":"无阻塞性冠状动脉疾病心绞痛患者有氧高强度间歇运动训练的可行性及生理效果","authors":"Alf Inge Larsen, Charlotte Sæland, Johnny Vegsundvåg, Mette Storebø Skadberg, Jorunn Nilsen, Noreen Butt, Anastasia Ushakova, Torstein Valborgland, Peter Scott Munk, Kjetil Isaksen","doi":"10.1093/ehjopen/oead030","DOIUrl":null,"url":null,"abstract":"<p><strong>Aims: </strong>Patients with chest pain and normal coronary angiogram [angina with normal coronary arteries (ANOCA)] constitute a therapeutic problem with considerable functional limitation and reduced quality of life. The aims of the current pilot study were to (i) explore if a structured aerobic high-intensity interval training (HIT) program for 12 weeks was feasible in patients with ANOCA, and (ii) to assess mechanisms related to symptoms in this population.</p><p><strong>Methods and results: </strong>Sixteen patients with ANOCA underwent a 3-month aerobic HIT program with one-to-one monitored exercise sessions on treadmill in a 4 min × 4 manner, three times a week. Four patients served as controls. Coronary flow velocity reserve (CFVR) transthoracic Doppler, flow-mediated vasodilation (FMD) and VO<sub>2max</sub> was measured at baseline and after 12 weeks. The average attendance to training sessions was 82.3% ± 10.1 (56-94). CFVR in the training group increased from 2.50 ± 0.48 to 3.04 ± 0.71 (<i>P</i> < 0.001) whereas FMD increased from 4.19 ± 2.42% to 8.28 ± 2.85% (<i>P</i> < 0.001). Improvement in CFVR correlated with the relative improvement in FMD (<i>R</i> = 0.45, <i>P</i> = 0.047). This was associated with an increase in VO<sub>2max</sub> from 28.75 ± 6.51 mL/kg/min to 31.93 ± 6.46 mL/kg/min (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>A 3-month program of monitored HIT was feasible, with high adherence resulting in improved functional capacity in patients with ANOCA. CFVR improved and this improvement was associated with improved FMD.</p><p><strong>Clinicaltrialsgov identifier: </strong>NCT02905630.</p>","PeriodicalId":11973,"journal":{"name":"European Heart Journal Open","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cc/fc/oead030.PMC10127938.pdf","citationCount":"0","resultStr":"{\"title\":\"Aerobic high-intensity interval exercise training in patients with angina and no obstructive coronary artery disease: feasibility and physiological effects.\",\"authors\":\"Alf Inge Larsen, Charlotte Sæland, Johnny Vegsundvåg, Mette Storebø Skadberg, Jorunn Nilsen, Noreen Butt, Anastasia Ushakova, Torstein Valborgland, Peter Scott Munk, Kjetil Isaksen\",\"doi\":\"10.1093/ehjopen/oead030\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aims: </strong>Patients with chest pain and normal coronary angiogram [angina with normal coronary arteries (ANOCA)] constitute a therapeutic problem with considerable functional limitation and reduced quality of life. The aims of the current pilot study were to (i) explore if a structured aerobic high-intensity interval training (HIT) program for 12 weeks was feasible in patients with ANOCA, and (ii) to assess mechanisms related to symptoms in this population.</p><p><strong>Methods and results: </strong>Sixteen patients with ANOCA underwent a 3-month aerobic HIT program with one-to-one monitored exercise sessions on treadmill in a 4 min × 4 manner, three times a week. Four patients served as controls. Coronary flow velocity reserve (CFVR) transthoracic Doppler, flow-mediated vasodilation (FMD) and VO<sub>2max</sub> was measured at baseline and after 12 weeks. The average attendance to training sessions was 82.3% ± 10.1 (56-94). CFVR in the training group increased from 2.50 ± 0.48 to 3.04 ± 0.71 (<i>P</i> < 0.001) whereas FMD increased from 4.19 ± 2.42% to 8.28 ± 2.85% (<i>P</i> < 0.001). Improvement in CFVR correlated with the relative improvement in FMD (<i>R</i> = 0.45, <i>P</i> = 0.047). This was associated with an increase in VO<sub>2max</sub> from 28.75 ± 6.51 mL/kg/min to 31.93 ± 6.46 mL/kg/min (<i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>A 3-month program of monitored HIT was feasible, with high adherence resulting in improved functional capacity in patients with ANOCA. CFVR improved and this improvement was associated with improved FMD.</p><p><strong>Clinicaltrialsgov identifier: </strong>NCT02905630.</p>\",\"PeriodicalId\":11973,\"journal\":{\"name\":\"European Heart Journal Open\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cc/fc/oead030.PMC10127938.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Heart Journal Open\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/ehjopen/oead030\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Heart Journal Open","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/ehjopen/oead030","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Aerobic high-intensity interval exercise training in patients with angina and no obstructive coronary artery disease: feasibility and physiological effects.
Aims: Patients with chest pain and normal coronary angiogram [angina with normal coronary arteries (ANOCA)] constitute a therapeutic problem with considerable functional limitation and reduced quality of life. The aims of the current pilot study were to (i) explore if a structured aerobic high-intensity interval training (HIT) program for 12 weeks was feasible in patients with ANOCA, and (ii) to assess mechanisms related to symptoms in this population.
Methods and results: Sixteen patients with ANOCA underwent a 3-month aerobic HIT program with one-to-one monitored exercise sessions on treadmill in a 4 min × 4 manner, three times a week. Four patients served as controls. Coronary flow velocity reserve (CFVR) transthoracic Doppler, flow-mediated vasodilation (FMD) and VO2max was measured at baseline and after 12 weeks. The average attendance to training sessions was 82.3% ± 10.1 (56-94). CFVR in the training group increased from 2.50 ± 0.48 to 3.04 ± 0.71 (P < 0.001) whereas FMD increased from 4.19 ± 2.42% to 8.28 ± 2.85% (P < 0.001). Improvement in CFVR correlated with the relative improvement in FMD (R = 0.45, P = 0.047). This was associated with an increase in VO2max from 28.75 ± 6.51 mL/kg/min to 31.93 ± 6.46 mL/kg/min (P < 0.001).
Conclusion: A 3-month program of monitored HIT was feasible, with high adherence resulting in improved functional capacity in patients with ANOCA. CFVR improved and this improvement was associated with improved FMD.
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