肾移植对常染色体显性多囊肾病囊肿生长的影响。

IF 1.1 4区 医学 Q3 UROLOGY & NEPHROLOGY
Jorge E Gaytan-Arocha, Aaron Pérez-Segovia, Estefania Reul-Linares, Elisa Naomi Hernández-Paredes, Mónica Chapa-Ibargüengoitia, Ricardo Correa-Rotter, Luis E Morales-Buenrostro, Juan C Ramirez-Sandoval
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引用次数: 0

摘要

背景:在常染色体显性多囊肾病(ADPKD)患者中,关于肾移植后囊肿进展率的证据有限。目的:比较-ADPKD肾移植受者(KTR)移植前后高度调节总肾体积(Ht-TKV)的变化。材料和方法:回顾性队列研究。Ht-TKV的估计是通过椭球体积方程计算的,使用移植前后CT或每年MRI扫描的测量结果。结果:我们纳入了30例接受肾移植的- adpkd患者(年龄49±10.1岁,11例(37%)女性,透析期3(1 - 6)年,4例(13%)在移植期接受单侧肾切除术)。中位随访时间为5年(2 - 16年)。移植与27例(90%)KTR移植后Ht-TKV显著降低相关。随访6年后,中位Ht-TKV从1708 (IQR 1100 - 2350) mL/m下降到710 (IQR 420 - 1380) mL/m。(p)结论:肾移植术后2年降低了Ht-TKV,且这种下降持续6年以上的随访。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of Kidney transplantation on cyst growth in autosomal dominant polycystic kidney disease.

Background: In patients with autosomal dominant polycystic kidney disease (ADPKD), there is limited evidence of the rate of cyst progression after kidney transplantation.

Aims: To compare the height-adjusted total kidney volume (Ht-TKV) before and after transplantation in kidney transplant recipients (KTR) with -ADPKD.

Materials and methods: Retrospective cohort study. The estimate of Ht-TKV was calculated by the ellipsoid volume equation using measurements from CT or yearly MRI scans before and after transplantation.

Results: We included 30 patients with -ADPKD who underwent kidney transplantation (age 49 ± 10.1 years, 11 (37%) females, dialysis vintage 3 (1 - 6) years, and 4 (13%) underwent unilateral nephrectomy during the peritransplant period). The median follow-up time was 5 years (range 2 - 16 years). Transplantation was associated with a significant decrease in Ht-TKV after transplantation in 27 (90%) KTR. Median Ht-TKV decreased from 1,708 (IQR 1,100 - 2,350) mL/m to 710 (IQR 420 - 1,380) mL/m after 6 years of follow-up (p < 0.001), with a mean Ht-TKV change rate per year after transplantation of -1.4, -11.8, -9.7, -12.7, -7.0, and -9.4% after 1, 2, 3, 4, 5, and 6 years, respectively. Even in 2 (7%) KTR without regression, the annual growth was < 1.5% per year after transplantation.

Conclusion: Kidney transplantation reduced Ht-TKV after the first 2 years of transplantation, and this decline was continuous for more than 6 years of follow-up.

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来源期刊
Clinical nephrology
Clinical nephrology 医学-泌尿学与肾脏学
CiteScore
2.10
自引率
9.10%
发文量
138
审稿时长
4-8 weeks
期刊介绍: Clinical Nephrology appears monthly and publishes manuscripts containing original material with emphasis on the following topics: prophylaxis, pathophysiology, immunology, diagnosis, therapy, experimental approaches and dialysis and transplantation.
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