曲霉共培养:对其次生代谢物和微生物相互作用的最新见解

IF 6.9 3区 医学 Q1 CHEMISTRY, MEDICINAL
Abdullah Alanzi, Esraa A. Elhawary, Mohamed L. Ashour, Ashaimaa Y. Moussa
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引用次数: 1

摘要

迫切需要新的抗生素来对抗新出现的耐药微生物菌株。其中最紧迫的资源是曲霉微生物共培养。曲霉物种的基因组包含的新基因簇的数量比以前预期的要多得多,新的策略和方法对于开发这一潜在的新药和药理学制剂至关重要。这是第一次回顾了曲霉共培养物的最新发展和化学多样性,并强调了其未开发的丰富性。分析数据表明,几种曲霉与其他微生物(包括细菌、植物和真菌)共培养是新型生物活性天然产物的来源。在曲霉共培养过程中新产生或增加了多种重要的化学骨架引线,其中包括紫杉醇、细胞chalasans、notamides、五肽、水飞蓟宾和联胺。在共培养中检测到霉菌毒素产生或完全消除的可能性,这为更好的去污染策略铺平了道路。大多数共培养由于其产生的化学模式而显示出其抗菌或细胞毒性行为的显著改善;例如,weldone和asperterrin分别具有较好的抗肿瘤和抗菌活性。微生物共培养引起了特定代谢物的上调或产生,其重要性和意义尚未揭示。近10年来,从曲霉共培养中分离出的化合物超过155种,在优化的共培养环境下表现出过量生产、减少或完全抑制,填补了药物化学家寻找新的铅源或生物活性分子作为抗癌剂或抗菌剂的空白。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Aspergillus co-cultures: A recent insight into their secondary metabolites and microbial interactions

Aspergillus co-cultures: A recent insight into their secondary metabolites and microbial interactions

There is an urgent need for novel antibiotics to combat emerging resistant microbial strains. One of the most pressing resources is Aspergillus microbial cocultures. The genome of Aspergillus species comprises a far larger number of novel gene clusters than previously expected, and novel strategies and approaches are essential to exploit this potential source of new drugs and pharmacological agents. This is the first review consulting recent developments and chemical diversity of Aspergillus cocultures and highlighting its untapped richness. The analyzed data revealed that cocultivation of several Aspergillus species with other microorganisms, including bacteria, plants, and fungi, is a source of novel bioactive natural products. Various vital chemical skeleton leads were newly produced or augmented in Aspergillus cocultures, among which were taxol, cytochalasans, notamides, pentapeptides, silibinin, and allianthrones. The possibility of mycotoxin production or complete elimination in cocultivations was detected, which pave the way for better decontamination strategies. Most cocultures revealed a remarkable improvement in their antimicrobial or cytotoxic behavior due to their produced chemical patterns; for instance, weldone and asperterrin whose antitumor and antibacterial activities, respectively, were superior. Microbial cocultivation elicited the upregulation or production of specific metabolites whose importance and significance are yet to be revealed. With more than 155 compounds isolated from Aspergillus cocultures in the last 10 years, showing overproduction, reduction, or complete suppression under the optimized coculture circumstances, this study filled a gap for medicinal chemists searching for new lead sources or bioactive molecules as anticancer agents or antimicrobials.

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来源期刊
CiteScore
13.40
自引率
9.00%
发文量
48
审稿时长
3.3 months
期刊介绍: Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.
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