{"title":"中国北方成年双胞胎握力的全基因组关联研究。","authors":"Jia Luo, Tianhao Zhang, Weijing Wang, Dongfeng Zhang","doi":"10.1080/03008207.2022.2104160","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Currently, new loci related to handgrip strength have been identified in genome-wide association studies. However, this topic is an understudied area in the Chinese population.</p><p><strong>Materials and methods: </strong>A total of 135 dizygotic twin pairs recruited from the Qingdao Twin Registry system were included in the present study. Using GEMMA, VEAGSE2, and PASCAL software for SNP-based analysis, gene-based analysis, and pathway-based analysis, respectively. The resulting SNPs were subjected to eQTL analysis.</p><p><strong>Results: </strong>Although none of the loci reach the statistically significant level (<i>p</i> < 5 × 10<sup>-8</sup>), we found 19 SNPs exceeding the suggestive significant level (<i>p</i> < 1 × 10<sup>-5</sup>). After imputation, 162 SNPs reached suggestive evidence level for handgrip strength. A total of 1,118 genes reached the nominal significance level (<i>p</i> < 0.05) in gene-based analysis. A total of 626 potential biological pathways were associated with handgrip strength (<i>p</i> < 0.05). The results of eQTL analysis were mainly enriched in tissues such as the muscle-skeletal, brain, visceral fat, and brain-cortical.</p><p><strong>Conclusions: </strong>Genetic variants may involve in regulatory domains, functional genes, and biological pathways that mediate handgrip strength.</p>","PeriodicalId":10661,"journal":{"name":"Connective Tissue Research","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Genome-wide association study of handgrip strength in the Northern Chinese adult twins.\",\"authors\":\"Jia Luo, Tianhao Zhang, Weijing Wang, Dongfeng Zhang\",\"doi\":\"10.1080/03008207.2022.2104160\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Currently, new loci related to handgrip strength have been identified in genome-wide association studies. However, this topic is an understudied area in the Chinese population.</p><p><strong>Materials and methods: </strong>A total of 135 dizygotic twin pairs recruited from the Qingdao Twin Registry system were included in the present study. Using GEMMA, VEAGSE2, and PASCAL software for SNP-based analysis, gene-based analysis, and pathway-based analysis, respectively. The resulting SNPs were subjected to eQTL analysis.</p><p><strong>Results: </strong>Although none of the loci reach the statistically significant level (<i>p</i> < 5 × 10<sup>-8</sup>), we found 19 SNPs exceeding the suggestive significant level (<i>p</i> < 1 × 10<sup>-5</sup>). After imputation, 162 SNPs reached suggestive evidence level for handgrip strength. A total of 1,118 genes reached the nominal significance level (<i>p</i> < 0.05) in gene-based analysis. A total of 626 potential biological pathways were associated with handgrip strength (<i>p</i> < 0.05). The results of eQTL analysis were mainly enriched in tissues such as the muscle-skeletal, brain, visceral fat, and brain-cortical.</p><p><strong>Conclusions: </strong>Genetic variants may involve in regulatory domains, functional genes, and biological pathways that mediate handgrip strength.</p>\",\"PeriodicalId\":10661,\"journal\":{\"name\":\"Connective Tissue Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2023-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Connective Tissue Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/03008207.2022.2104160\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Connective Tissue Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/03008207.2022.2104160","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Genome-wide association study of handgrip strength in the Northern Chinese adult twins.
Purpose: Currently, new loci related to handgrip strength have been identified in genome-wide association studies. However, this topic is an understudied area in the Chinese population.
Materials and methods: A total of 135 dizygotic twin pairs recruited from the Qingdao Twin Registry system were included in the present study. Using GEMMA, VEAGSE2, and PASCAL software for SNP-based analysis, gene-based analysis, and pathway-based analysis, respectively. The resulting SNPs were subjected to eQTL analysis.
Results: Although none of the loci reach the statistically significant level (p < 5 × 10-8), we found 19 SNPs exceeding the suggestive significant level (p < 1 × 10-5). After imputation, 162 SNPs reached suggestive evidence level for handgrip strength. A total of 1,118 genes reached the nominal significance level (p < 0.05) in gene-based analysis. A total of 626 potential biological pathways were associated with handgrip strength (p < 0.05). The results of eQTL analysis were mainly enriched in tissues such as the muscle-skeletal, brain, visceral fat, and brain-cortical.
Conclusions: Genetic variants may involve in regulatory domains, functional genes, and biological pathways that mediate handgrip strength.
期刊介绍：
The aim of Connective Tissue Research is to present original and significant research in all basic areas of connective tissue and matrix biology.
The journal also provides topical reviews and, on occasion, the proceedings of conferences in areas of special interest at which original work is presented.
The journal supports an interdisciplinary approach; we present a variety of perspectives from different disciplines, including
Biochemistry
Cell and Molecular Biology
Immunology
Structural Biology
Biophysics
Biomechanics
Regenerative Medicine
The interests of the Editorial Board are to understand, mechanistically, the structure-function relationships in connective tissue extracellular matrix, and its associated cells, through interpretation of sophisticated experimentation using state-of-the-art technologies that include molecular genetics, imaging, immunology, biomechanics and tissue engineering.
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