坎地沙坦治疗对心肌梗死后患者心脏重构超声心动图指标的影响。

IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Hüseyin Tezcan, Abdullah Tunçez, Kenan Demir, Bulent Behlül Altunkeser, Nazif Aygül, Muhammed Ulvi Yalcin, Muhammed Salih Ates, Canan Aydoğan, Onur Can Polat, Aslıhan Merve Toprak
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引用次数: 0

摘要

目的:心肌梗死对心肌的结构和功能特性产生不利影响,即心肌重构。左室质量、左室质量指数和相对壁厚是心脏重构的重要预测指标。在本研究中,我们比较了坎地沙坦治疗与佐非普利治疗对心肌梗死后患者心脏重构超声心动图指标的影响。材料和方法:在这项前瞻性研究中,成功接受经皮冠状动脉介入治疗的患者被随机分配到坎地沙坦或佐非诺普利治疗组。随机分组后,在治疗开始前评估心脏重构的超声心动图指标,包括左心室质量、左心室质量指数和相对壁厚,并进行1个月和6个月的随访。结果:根据我们的研究,坎地沙坦组在随访6个月时左室质量和左室质量指数与基线值相比显著降低(199.53±38.51 g vs. 212.69±40.82 g;99.05 g/m2 (90.0 ~ 116.5) vs. 106.0 g/m2(96.0 ~ 123.00),结论:我们的研究结果表明,心肌梗死后坎地沙坦治疗可能对改善心肌梗死后心脏重构有潜在的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of candesartan treatment on echocardiographic indices of cardiac remodeling in post-myocardial infarction patients.

Objective: Myocardial infarction has unfavorable effect on structural and functional properties of the myocardium, referred to as cardiac remodeling. Left ventricular mass, left ventricular mass index, and relative wall thickness are important predictors of cardiac remodeling. In this study, we investigated the effect of candesartan treatment in comparison with zofenopril treatment on echocardiographic indices of cardiac remodeling in post myocardial infarction patients.

Material and methods: In this prospective study, patients who underwent successful percutaneous coronary intervention were randomly assigned to a candesartan or zofenopril treatment. After randomization, echocardiographic indices of cardiac remodeling including left ventricular mass, left ventricular mass index, and relative wall thickness were evaluated before the start of treatment along with 1- and 6-month follow-ups.

Results: According to our study, candesartan group showed significant reduction of estimated left ventricular mass and left ventricular mass index at 6-month follow-up visit compared to baseline values (199.53±38.51 g vs. 212.69±40.82 g; 99.05 g/m2 (90.00-116.5) vs. 106.0 g/m2 (96.0∼123.00), p<0.05, respectively). This trend was also observed in zofenopril group during the 6-month period (201.22±40.07 g vs. 207.52±41.61 g; 101.0 g/m2 (92.25-111.75.0) vs. 104.50 g/m2 (95.0∼116.75), p<0.05, respectively). Although both classes of drugs had favorable effects on post-myocardial infarction cardiac remodeling, the absolute benefit was more prominent in candesartan group as compared to zofenopril group (p<0.05).

Conclusion: Our results suggest that candesartan treatment following myocardial infarction may potentially be useful in terms of improving post-myocardial infarction cardiac remodeling.

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来源期刊
CiteScore
2.20
自引率
0.00%
发文量
276
审稿时长
12 weeks
期刊介绍: A Revista da Associação Médica Brasileira (RAMB), editada pela Associação Médica Brasileira, desde 1954, tem por objetivo publicar artigos que contribuam para o conhecimento médico.
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